Spdya MGI Mouse Gene Detail - MGI:1918141 - speedy/RINGO cell cycle regulator family, member A

Symbol

Spdya
Name

speedy/RINGO cell cycle regulator family, member A
Synonyms

4921517J08Rik, 4930548B21Rik, Spdy1, speedy A1, speedy A2, speedy/ringo

Feature Type

protein coding gene
IDs

MGI:1918141
NCBI Gene: 70891
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr17:71859056-71896528 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 41.87 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

957 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918141	protein coding gene	Chr17:71833890-71896528 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024010	protein coding gene	Chr17:74012971-74052157 (+)
A/J	MGP_AJ_G0023968	protein coding gene	Chr17:71771278-71808480 (+)
AKR/J	MGP_AKRJ_G0023937	protein coding gene	Chr17:72735502-72774035 (+)
BALB/cJ	MGP_BALBcJ_G0023969	protein coding gene	Chr17:71698667-71739671 (+)
C3H/HeJ	MGP_C3HHeJ_G0023733	protein coding gene	Chr17:73698775-73736026 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024415	protein coding gene	Chr17:76725201-76762651 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021860	protein coding gene	Chr17:67522124-67559120 (+)
CAST/EiJ	MGP_CASTEiJ_G0023214	protein coding gene	Chr17:74130394-74173206 (+)
CBA/J	MGP_CBAJ_G0023708	protein coding gene	Chr17:79913834-79952943 (+)
DBA/2J	MGP_DBA2J_G0023837	protein coding gene	Chr17:70426599-70463744 (+)
FVB/NJ	MGP_FVBNJ_G0023803	protein coding gene	Chr17:69899663-69937512 (+)
LP/J	MGP_LPJ_G0023919	protein coding gene	Chr17:74749734-74787142 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023831	protein coding gene	Chr17:79764862-79804600 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024459	protein coding gene	Chr17:73262996-73300465 (+)
PWK/PhJ	MGP_PWKPhJ_G0022960	protein coding gene	Chr17:69737828-69776589 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022771	protein coding gene	Chr17:69968829-70009263 (+)
WSB/EiJ	MGP_WSBEiJ_G0023281	protein coding gene	Chr17:74095754-74135538 (+)

Human Ortholog

SPDYA, speedy/RINGO cell cycle regulator family member A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPDYA, speedy/RINGO cell cycle regulator family member A
Synonyms

RINGO3, RINGOA, SPDY1, SPY1
Links

HGNC:30613

NCBI Gene ID: 245711

neXtProt AC: NX_Q5MJ70

UniProt: Q5MJ70
Chr Location

2p23.2; chr2:28782517-28850611 (+) GRCh38

MGI Vertebrate Homology

Spdya stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SPDYA
Gene Tree

Spdya

less

Phenotype Summary

18 phenotypes from 2 alleles in 1 genetic background
3 images
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene results in impaired telomere attachment to the nuclear envelope during early meiosis, abnormal chromosome pairing and homologous synapsis, and meiotic prophase I arrest in male and female germ cells leading to infertility in both sexes.

less

All GO Annotations

36
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

869
Tissues

114
cDNA Data

10
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase spdya

ZFIN spdya

less

All Sequences

51
RefSeq

13
UniProt

3
CCDS

CCDS50178.1, CCDS50179.1

Ensembl

ENSMUSG00000052525 (Evidence)
NCBI Gene

70891

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052525	Ensembl Gene Model \| MGI Sequence Detail	37473	C57BL/6J	± kb
transcript	ENSMUST00000144142	Ensembl \| MGI Sequence Detail	933	Not Applicable
polypeptide	ENSMUSP00000118994	Ensembl \| MGI Sequence Detail	310	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000015509 speedy protein A

(term hierarchy)
InterPro Domains

IPR020984 Cell cycle regulatory protein Speedy

IPR052316 Speedy/Ringo cell cycle regulator

less

All nucleic 14

cDNA 11

Primer pair 2

Other 1

Microarray probesets 3

less

MGI:1922581

Summaries

All 44

Developmental Gene Expression 7

Gene Ontology 8

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:355737 Wang D, et al., SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1. Cell Death Differ. 2023 Feb;30(2):369-382

TSS for Spdya:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145751	Chr17:71859026-71859074 (+)	-6 bp
Tssr145752	Chr17:71859078-71859089 (+)	28 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24