Phyhipl MGI Mouse Gene Detail - MGI:1918161 - phytanoyl-CoA hydroxylase interacting protein-like

Symbol

Phyhipl
Name

phytanoyl-CoA hydroxylase interacting protein-like
Synonyms

4921522K17Rik, PHY2

Feature Type

protein coding gene
IDs

MGI:1918161
NCBI Gene: 70911
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr10:70393516-70435121 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 36.69 cM
Mapping Data

2 experiments

SNPs within 2kb

1078 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918161	protein coding gene	Chr10:70393512-70491795 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017339	protein coding gene	Chr10:70503361-70603259 (-)
A/J	MGP_AJ_G0017316	protein coding gene	Chr10:68105509-68202162 (-)
AKR/J	MGP_AKRJ_G0017277	protein coding gene	Chr10:69960175-70058433 (-)
BALB/cJ	MGP_BALBcJ_G0017276	protein coding gene	Chr10:68303529-68400664 (-)
C3H/HeJ	MGP_C3HHeJ_G0017100	protein coding gene	Chr10:69987825-70086302 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017734	protein coding gene	Chr10:73045316-73148955 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015424	protein coding gene	Chr10:64711577-64813000 (-)
CAST/EiJ	MGP_CASTEiJ_G0016670	protein coding gene	Chr10:70133355-70240895 (-)
CBA/J	MGP_CBAJ_G0017072	protein coding gene	Chr10:75871956-75975459 (-)
DBA/2J	MGP_DBA2J_G0017177	protein coding gene	Chr10:67455063-67552100 (-)
FVB/NJ	MGP_FVBNJ_G0017170	protein coding gene	Chr10:66631432-66732592 (-)
LP/J	MGP_LPJ_G0017250	protein coding gene	Chr10:70967170-71066401 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017198	protein coding gene	Chr10:77954749-78063668 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017773	protein coding gene	Chr10:69915341-70013917 (-)
PWK/PhJ	MGP_PWKPhJ_G0016454	protein coding gene	Chr10:67318078-67418186 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016236	protein coding gene	Chr10:69301955-69402383 (-)
WSB/EiJ	MGP_WSBEiJ_G0016734	protein coding gene	Chr10:69874066-69974459 (-)

Human Ortholog

PHYHIPL, phytanoyl-CoA 2-hydroxylase interacting protein like

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PHYHIPL, phytanoyl-CoA 2-hydroxylase interacting protein like
Links

HGNC:29378

NCBI Gene ID: 84457

neXtProt AC: NX_Q96FC7

UniProt: Q96FC7
Chr Location

10q21.1; chr10:59173597-59247774 (+) GRCh38

MGI Vertebrate Homology

Phyhipl stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PHYHIPL
Gene Tree

Phyhipl

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Phyhipl
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal cerebellar Purkinje cell morphology and innervation, decreased formation of molecular layer interneuron-Purkinje cell synapses, and impaired motor coordination.

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All GO Annotations

3
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

817
Tissues

17
cDNA Data

39
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase phyhipl

ZFIN phyhiplb

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All Sequences

55
RefSeq

6
UniProt

4
CCDS

CCDS23914.1, CCDS48593.1

Ensembl

ENSMUSG00000037747 (Evidence)
NCBI Gene

70911

			Length	Strain/Species	Flank
genomic	70911	NCBI Gene Model \| MGI Sequence Detail	41606	C57BL/6J	± kb
transcript	NM_178621	RefSeq \| MGI Sequence Detail	2873	C57BL/6
polypeptide	Q8BGT8	UniProt \| EBI \| MGI Sequence Detail	375	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012677 phytanoyl-CoA hydroxylase-interacting protein-like

(term hierarchy)
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR042868 Phytanoyl-CoA hydroxylase-interacting protein-like

IPR045545 Phytanoyl-CoA hydroxylase-interacting protein-like, C-terminal
GlyGen

Q8BGT8 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 40

cDNA 40

Microarray probesets 2

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MGI:2143557

Summaries

All 35

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:307852 Sugimoto H, et al., The Ser19Stop single nucleotide polymorphism (SNP) of human PHYHIPL affects the cerebellum in mice. Mol Brain. 2021 Mar 12;14(1):52

TSS for Phyhipl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98048	Chr10:70435144-70435153 (-)	-28 bp
Tssr3243	Chr10:70435139-70435142 (-)	-20 bp
Tssr98047	Chr10:70435114-70435131 (-)	-2 bp
Tssr98046	Chr10:70435101-70435112 (-)	14 bp
Tssr98045	Chr10:70428690-70428695 (-)	6,428 bp
Tssr98044	Chr10:70428612-70428678 (-)	6,476 bp
Tssr3242	Chr10:70428601-70428606 (-)	6,517 bp
Tssr98043	Chr10:70395243-70395260 (-)	39,869 bp
Tssr98042	Chr10:70395051-70395086 (-)	40,052 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24