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Cdkn2aip Gene Detail
Summary
  • Symbol
    Cdkn2aip
  • Name
    CDKN2A interacting protein
  • Synonyms
    4921511I16Rik, CARF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918175
    NCBI Gene: 70925
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:48162379-48166966 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 26.88 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918175
 protein coding gene Chr8:48162379-48166967 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033600
 protein coding gene Chr8:46897242-46901867 (-)
A/J MGP_AJ_G0033582
 protein coding gene Chr8:45060917-45065504 (-)
AKR/J MGP_AKRJ_G0033507
 protein coding gene Chr8:46369988-46374575 (-)
BALB/cJ MGP_BALBcJ_G0033579
 protein coding gene Chr8:45240413-45245000 (-)
C3H/HeJ MGP_C3HHeJ_G0033288
 protein coding gene Chr8:46934187-46938774 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034095
 protein coding gene Chr8:48649340-48660501 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031044
 protein coding gene Chr8:41293451-41298025 (-)
CAST/EiJ MGP_CASTEiJ_G0032614
 protein coding gene Chr8:46384498-46389091 (-)
CBA/J MGP_CBAJ_G0033267
 protein coding gene Chr8:50593088-50597661 (-)
DBA/2J MGP_DBA2J_G0033420
 protein coding gene Chr8:44862600-44867188 (-)
FVB/NJ MGP_FVBNJ_G0033361
 protein coding gene Chr8:44338740-44343339 (-)
LP/J MGP_LPJ_G0033508
 protein coding gene Chr8:46890214-46894809 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0034113
 protein coding gene Chr8:46555455-46560028 (-)
PWK/PhJ MGP_PWKPhJ_G0032322
 protein coding gene Chr8:44386946-44391586 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032158
 protein coding gene Chr8:45719492-45727888 (-)
WSB/EiJ MGP_WSBEiJ_G0032730
 protein coding gene Chr8:46815065-46819652 (-)



Homology
more
  • Human Ortholog
    CDKN2AIP, CDKN2A interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDKN2AIP, CDKN2A interacting protein
  • Links
    NCBI Gene ID: 55602
    neXtProt AC: NX_Q9NXV6
    UniProt: Q9NXV6

  • Chr Location
    4q35.1; chr4:183444635-183449064 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    22
  • cDNA Data
    33
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70925 NCBI Gene Model | MGI Sequence Detail 4588 C57BL/6J ±  kb
    transcript NM_172407 RefSeq | MGI Sequence Detail 3494 C57BL/6  
    polypeptide Q8BI72 UniProt | EBI | MGI Sequence Detail 563 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005276 CDKN2A-interacting protein
      (term hierarchy)
    • InterPro Domains
      IPR014720 Double-stranded RNA-binding domain
      IPR021859 XRN2-binding (XTBD) domain
    • GlyGen
      Q8BI72 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 34
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2142775
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 5
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory