Nol8 MGI Mouse Gene Detail - MGI:1918180

Symbol

Nol8
Name

nucleolar protein 8
Synonyms

4921532D18Rik, 5730412B09Rik, D13Ertd548e

Feature Type

protein coding gene
IDs

MGI:1918180
NCBI Gene: 70930
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr13:49806554-49832492 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 25.36 cM, cytoband B1
Mapping Data

4 experiments

SNPs within 2kb

636 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918180	protein coding gene	Chr13:49806554-49832492 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020541	protein coding gene	Chr13:48632666-48662300 (+)
A/J	MGP_AJ_G0020495	protein coding gene	Chr13:46922337-46950046 (+)
AKR/J	MGP_AKRJ_G0020472	protein coding gene	Chr13:48242615-48268125 (+)
BALB/cJ	MGP_BALBcJ_G0020491	protein coding gene	Chr13:47124616-47151726 (+)
C3H/HeJ	MGP_C3HHeJ_G0020290	protein coding gene	Chr13:48060246-48087080 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020924	protein coding gene	Chr13:50106775-50133898 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018509	protein coding gene	Chr13:44871915-44897326 (+)
CAST/EiJ	MGP_CASTEiJ_G0019805	protein coding gene	Chr13:48077326-48102872 (+)
CBA/J	MGP_CBAJ_G0020251	protein coding gene	Chr13:52177011-52202686 (+)
DBA/2J	MGP_DBA2J_G0020373	protein coding gene	Chr13:46430383-46460419 (+)
FVB/NJ	MGP_FVBNJ_G0020352	protein coding gene	Chr13:45962319-45988150 (+)
LP/J	MGP_LPJ_G0020448	protein coding gene	Chr13:48854048-48882659 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020381	protein coding gene	Chr13:51882026-51909842 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020967	protein coding gene	Chr13:47923848-47951353 (+)
PWK/PhJ	MGP_PWKPhJ_G0019561	protein coding gene	Chr13:46619573-46645314 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019389	protein coding gene	Chr13:46631329-46660875 (+)
WSB/EiJ	MGP_WSBEiJ_G0019867	protein coding gene	Chr13:48255708-48281330 (+)

Human Ortholog

NOL8, nucleolar protein 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NOL8, nucleolar protein 8
Synonyms

bA62C3.3, bA62C3.4, C9orf34, NOP132
Links

HGNC:23387

NCBI Gene ID: 55035

neXtProt AC: NX_Q76FK4

UniProt: Q76FK4
Chr Location

9q22.31; chr9:92297358-92325636 (-) GRCh38

MGI Vertebrate Homology

Nol8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NOL8
Gene Tree

Nol8

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

10
Targeted

4
Genomic Mutations

1 involving Nol8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

22
cDNA Data

128
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nol8

ZFIN nol8

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All Sequences

67
RefSeq

10
UniProt

5
CCDS

CCDS36658.1

Ensembl

ENSMUSG00000021392 (Evidence)
NCBI Gene

70930

			Length	Strain/Species	Flank
genomic	70930	NCBI Gene Model \| MGI Sequence Detail	25939	C57BL/6J	± kb
transcript	NR_073167	RefSeq \| MGI Sequence Detail	4836	ZRU/MplStud
polypeptide	Q3UHX0	UniProt \| EBI \| MGI Sequence Detail	1147	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000011314 nucleolar protein 8

(term hierarchy)
InterPro Domains

IPR034138 Nucleolar protein 8, RNA recognition motif

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain
GlyGen

Q3UHX0 1 site, 1 O-linked glycan (1 site)

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All nucleic 130

cDNA 128

Primer pair 2

Microarray probesets 6

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MGI:1261804, MGI:1917742

Summaries

All 44

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 15
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nol8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119728	Chr13:49806543-49806573 (+)	4 bp
Tssr119729	Chr13:49806574-49806612 (+)	39 bp
Tssr119730	Chr13:49806773-49806843 (+)	254 bp
Tssr119731	Chr13:49807876-49807894 (+)	1,331 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24