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Eva1c Gene Detail
Summary
  • Symbol
    Eva1c
  • Name
    eva-1 homolog C
  • Synonyms
    1700092M14Rik, 4931408A02Rik, Fam176c
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918217
    NCBI Gene: 70967
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:90623607-90701997 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 52.02 cM, cytoband C3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2724 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918217
 protein coding gene Chr16:90623607-90701997 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0022998
 protein coding gene Chr16:87514061-87594349 (+)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0023000
 protein coding gene Chr16:88035437-88114937 (+)
C3H/HeJ MGP_C3HHeJ_G0022761
 protein coding gene Chr16:90715665-90798796 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023447
 protein coding gene Chr16:94778663-94863257 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020949
 protein coding gene Chr16:85218940-85294295 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0022730
 protein coding gene Chr16:98815530-98915114 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0022838
 protein coding gene Chr16:86542121-86622687 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0022859
 protein coding gene Chr16:103381568-103476676 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023465
 protein coding gene Chr16:90660466-90741504 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0022332
 protein coding gene Chr16:90894530-90979127 (+)



Homology
more
  • Human Ortholog
    EVA1C, eva-1 homolog C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EVA1C, eva-1 homolog C
  • Synonyms
    B18, B19, C21orf63, C21orf64, FAM176C, PRED34, SUE21
  • Links
    NCBI Gene ID: 59271
    neXtProt AC: NX_P58658
    UniProt: P58658

  • Chr Location
    21q22.11; chr21:32411723-32515397 (+)  GRCh38
Human Diseases
less
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Endonuclease-mediated
    3
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    7
  • Genomic Mutations
    8 involving Eva1c
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    28 strains or lines available
Homozygous mice exhibit an abnormal pupilary reflex in response to dilating drugs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    942
  • Tissues
    184
  • cDNA Data
    11
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 70967 NCBI Gene Model | MGI Sequence Detail 78391 C57BL/6J ±  kb
transcript NM_001199210 RefSeq | MGI Sequence Detail 2366 C57BL/6  
polypeptide P58659 UniProt | EBI | MGI Sequence Detail 440 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000032508 protein FAM176C
    (term hierarchy)
  • InterPro Domains
    IPR000922 D-galactoside/L-rhamnose binding SUEL lectin domain
    IPR043159 D-galactoside/L-rhamnose binding SUEL lectin domain superfamily
    IPR039500 EVA1 domain
    IPR052461 EVA1 family of programmed cell death regulators
  • GlyGen
    P58659 3 sites, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 15
    cDNA 11
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1920793
References
more
  • Summaries
    All 105
    Developmental Gene Expression 7
    Diseases 4
    Gene Ontology 4
    Phenotypes 75
  • Earliest
    J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
  • Latest
    J:335294 Redhead Y, et al., Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development. 2023 Apr 15;150(8):dev201077
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory