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Mterf1a Gene Detail
Summary
  • Symbol
    Mterf1a
  • Name
    mitochondrial transcription termination factor 1a
  • Synonyms
    4931431L11Rik, 9230106K09Rik, Mterf, Mterf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918240
    NCBI Gene: 545725
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr5:3940581-3943933 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 2.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    174 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918240
 protein coding gene Chr5:3914576-3943933 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J MGP_AKRJ_G0029178
 protein coding gene Chr5:597553-603468 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0028967
 protein coding gene Chr5:781241-782680 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029696
 protein coding gene Chr5:984288-987863 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026942
 protein coding gene Chr5:922393-923294 (+)
CAST/EiJ MGP_CASTEiJ_G0028379
 protein coding gene Chr5:803804-819967 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0029079
 protein coding gene Chr5:758166-761401 (-)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0029727
 protein coding gene Chr5:724357-734459 (-)
PWK/PhJ MGP_PWKPhJ_G0028102
 protein coding gene Chr5:1056802-1058146 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027937
 protein coding gene Chr5:1527945-1529299 (-)
WSB/EiJ MGP_WSBEiJ_G0028459
 protein coding gene Chr5:750245-764918 (-)



Homology
more
  • Human Ortholog
    MTERF1, mitochondrial transcription termination factor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTERF1, mitochondrial transcription termination factor 1
  • Synonyms
    MTERF
  • Links
    NCBI Gene ID: 7978
    neXtProt AC: NX_Q99551
    UniProt: Q99551

  • Chr Location
    7q21.2; chr7:91692008-91880702 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    7 phenotype references
Mice homozygous for a knock-out allele of both Mterf1a and Mterf1b exhibit impaired transcription initiation at light-strand promoters resulting in a decrease of de novo transcription and reduced 7S RNA.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040429 Ensembl Gene Model | MGI Sequence Detail 3353 C57BL/6J ±  kb
transcript ENSMUST00000044746 Ensembl | MGI Sequence Detail 1376 Not Applicable  
polypeptide ENSMUSP00000046017 Ensembl | MGI Sequence Detail 379 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR038538 MTERF superfamily, mitochondrial/chloroplastic
    IPR003690 Transcription termination factor, mitochondrial/chloroplastic
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 1
Other
Accession IDs
less
MGI:1925325
References
more
  • Summaries
    All 28
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:198969 Terzioglu M, et al., MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation. Cell Metab. 2013 Apr 2;17(4):618-26
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory