Hsfy2 MGI Mouse Gene Detail - MGI:1918316 - heat shock transcription factor, Y-linked 2

Symbol

Hsfy2
Name

heat shock transcription factor, Y-linked 2
Synonyms

4933413G11Rik

Feature Type

protein coding gene
IDs

MGI:1918316
NCBI Gene: 71066
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:56675203-56676594 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 28.72 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

109 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918316	protein coding gene	Chr1:56675203-56676610 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016037	protein coding gene	Chr1:56424127-56425518 (-)
A/J	MGP_AJ_G0016020	protein coding gene	Chr1:54461267-54462658 (-)
AKR/J	MGP_AKRJ_G0015976	protein coding gene	Chr1:55910138-55911529 (-)
BALB/cJ	MGP_BALBcJ_G0015975	protein coding gene	Chr1:54499344-54500735 (-)
C3H/HeJ	MGP_C3HHeJ_G0015807	protein coding gene	Chr1:56191013-56192404 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016428	protein coding gene	Chr1:58755398-58756789 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014149	protein coding gene	Chr1:50451235-50452627 (-)
CAST/EiJ	MGP_CASTEiJ_G0015389	protein coding gene	Chr1:55451258-55452649 (-)
CBA/J	MGP_CBAJ_G0015779	protein coding gene	Chr1:60444484-60445875 (-)
DBA/2J	MGP_DBA2J_G0015880	protein coding gene	Chr1:53877080-53878471 (-)
FVB/NJ	MGP_FVBNJ_G0015882	protein coding gene	Chr1:53204614-53206005 (-)
LP/J	MGP_LPJ_G0015952	protein coding gene	Chr1:57297156-57298547 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015902	protein coding gene	Chr1:63514972-63516363 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016475	protein coding gene	Chr1:55902357-55903748 (-)
PWK/PhJ	MGP_PWKPhJ_G0015175	protein coding gene	Chr1:53208486-53209878 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014956	protein coding gene	Chr1:55490383-55491774 (-)
WSB/EiJ	MGP_WSBEiJ_G0015452	protein coding gene	Chr1:55570147-55571538 (-)

Human Ortholog

HSFY1, heat shock transcription factor Y-linked 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HSFY1, heat shock transcription factor Y-linked 1
Synonyms

HSF2L, HSFY
Links

HGNC:18568

NCBI Gene ID: 86614

neXtProt AC: NX_Q96LI6

UniProt: Q96LI6
Chr Location

Yq11.222; chrY:18529643-18588963 (+) GRCh38

Human Ortholog

HSFY2, heat shock transcription factor Y-linked 2
Synonyms

HSF2L, HSFY
Links

HGNC:23950

NCBI Gene ID: 159119

neXtProt AC: NX_Q96LI6

UniProt: Q96LI6
Chr Location

Yq11.222

MGI Vertebrate Homology

Hsfy2 stringent orthology
2 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: HSFY1, HSFY2
Gene Tree

Hsfy2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Hsfy2
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

3
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

10
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

29
RefSeq

2
UniProt

2
CCDS

CCDS14964.1

Ensembl

ENSMUSG00000045336 (Evidence)
NCBI Gene

71066

			Length	Strain/Species	Flank
genomic	ENSMUSG00000045336	Ensembl Gene Model \| MGI Sequence Detail	1392	C57BL/6J	± kb
transcript	ENSMUST00000062085	Ensembl \| MGI Sequence Detail	1392	Not Applicable
polypeptide	ENSMUSP00000049715	Ensembl \| MGI Sequence Detail	392	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR000232 Heat shock factor (HSF)-type, DNA-binding

IPR027725 Heat shock transcription factor family

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 10

cDNA 10

Microarray probesets 2

Summaries

All 28

Developmental Gene Expression 2

Gene Ontology 1

Phenotypes 9
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:347775 Yoshimura S, et al., Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions. Nat Commun. 2024 Apr 29;15(1):3330

TSS for Hsfy2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11737	Chr1:56676620-56676639 (-)	-36 bp
Tssr11736	Chr1:56676614-56676619 (-)	-23 bp
Tssr11735	Chr1:56676589-56676608 (-)	-5 bp
Tssr11734	Chr1:56676584-56676588 (-)	8 bp
Tssr11733	Chr1:56676567-56676574 (-)	23 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24