Stox2 MGI Mouse Gene Detail - MGI:1918319

Symbol

Stox2
Name

storkhead box 2
Synonyms

4933409N07Rik, mKIAA1392

Feature Type

protein coding gene
IDs

MGI:1918319
NCBI Gene: 71069
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr8:47633083-47866943 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 26.61 cM
Mapping Data

2 experiments

SNPs within 2kb

6965 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918319	protein coding gene	Chr8:47633083-47899397 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033594	protein coding gene	Chr8:46326148-46507469 (-)
A/J	MGP_AJ_G0033576	protein coding gene	Chr8:44529032-44704936 (-)
AKR/J	MGP_AKRJ_G0033501	protein coding gene	Chr8:45820309-45998077 (-)
BALB/cJ	MGP_BALBcJ_G0033573	protein coding gene	Chr8:44701715-44875238 (-)
C3H/HeJ	MGP_C3HHeJ_G0033282	protein coding gene	Chr8:46366222-46552046 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034089	protein coding gene	Chr8:48075329-48254718 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031038	protein coding gene	Chr8:40771075-40871104 (-)
CAST/EiJ	MGP_CASTEiJ_G0032608	protein coding gene	Chr8:45821006-46004948 (-)
CBA/J	MGP_CBAJ_G0033261	protein coding gene	Chr8:50015532-50198476 (-)
DBA/2J	MGP_DBA2J_G0033414	protein coding gene	Chr8:44323633-44496280 (-)
FVB/NJ	MGP_FVBNJ_G0033355	protein coding gene	Chr8:43796198-43972268 (-)
LP/J	MGP_LPJ_G0033502	protein coding gene	Chr8:46337185-46518119 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033400	protein coding gene	Chr8:50045003-50225256 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034107	protein coding gene	Chr8:45998633-46177875 (-)
PWK/PhJ	MGP_PWKPhJ_G0032316	protein coding gene	Chr8:43847330-44026219 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032152	protein coding gene	Chr8:45171036-45358089 (-)
WSB/EiJ	MGP_WSBEiJ_G0032724	protein coding gene	Chr8:46258192-46436481 (-)

Human Ortholog

STOX2, storkhead box 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

STOX2, storkhead box 2
Links

HGNC:25450

NCBI Gene ID: 56977

neXtProt AC: NX_Q9P2F5

UniProt: Q9P2F5
Chr Location

4q35.1; chr4:183797692-184023530 (+) GRCh38

MGI Vertebrate Homology

Stox2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: STOX2
Gene Tree

Stox2

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

3
Targeted

5
Genomic Mutations

1 involving Stox2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

84 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

50
cDNA Data

111
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA STOX2

Xenbase stox2

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All Sequences

99
RefSeq

34
UniProt

4
CCDS

CCDS40336.1, CCDS52548.1, CCDS85535.1

Ensembl

ENSMUSG00000038143 (Evidence)
NCBI Gene

71069

			Length	Strain/Species	Flank
genomic	71069	NCBI Gene Model \| MGI Sequence Detail	233861	C57BL/6J	± kb
transcript	NM_001363119	RefSeq \| MGI Sequence Detail	10562	C57BL/6
polypeptide	Q499E5	UniProt \| EBI \| MGI Sequence Detail	926	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000015770 storkhead-box protein 2

(term hierarchy)
InterPro Domains

IPR040126 Storkhead-box protein 1/2

IPR019391 Storkhead-box protein, winged-helix domain
GlyGen

Q499E5 1 site, 1 O-linked glycan (1 site)

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All nucleic 111

cDNA 111

Microarray probesets 5

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MGI:2142545, MGI:2142620

Summaries

All 43

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Stox2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr81235	Chr8:47866868-47866890 (-)	64 bp
Tssr81234	Chr8:47866814-47866861 (-)	105 bp
Tssr81233	Chr8:47866681-47866721 (-)	242 bp
Tssr81232	Chr8:47805521-47805536 (-)	61,414 bp
Tssr81231	Chr8:47805387-47805402 (-)	61,548 bp
Tssr81230	Chr8:47776201-47776210 (-)	90,737 bp
Tssr2563	Chr8:47742675-47742683 (-)	124,264 bp
Tssr81229	Chr8:47742448-47742496 (-)	124,471 bp
Tssr81228	Chr8:47742429-47742446 (-)	124,505 bp
Tssr81227	Chr8:47742389-47742419 (-)	124,539 bp
Tssr81226	Chr8:47742358-47742384 (-)	124,572 bp
Tssr81225	Chr8:47741482-47741511 (-)	125,446 bp
Tssr81224	Chr8:47741319-47741330 (-)	125,618 bp
Tssr81223	Chr8:47741165-47741195 (-)	125,763 bp
Tssr81222	Chr8:47720973-47720978 (-)	145,967 bp
Tssr81221	Chr8:47707795-47707808 (-)	159,141 bp
Tssr2562	Chr8:47702334-47702335 (-)	164,608 bp
Tssr81220	Chr8:47673654-47673665 (-)	193,283 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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