Tssk4 MGI Mouse Gene Detail - MGI:1918349 - testis-specific serine kinase 4

Symbol

Tssk4
Name

testis-specific serine kinase 4
Synonyms

1700020B19Rik, 4933424F08Rik

Feature Type

protein coding gene
IDs

MGI:1918349
NCBI Gene: 71099
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr14:55887641-55889996 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.19 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

95 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918349	protein coding gene	Chr14:55880893-55889996 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021359	protein coding gene	Chr14:49691961-49694318 (+)
A/J	MGP_AJ_G0021318	protein coding gene	Chr14:48699905-48702262 (+)
AKR/J	MGP_AKRJ_G0021294	protein coding gene	Chr14:50444940-50447297 (+)
BALB/cJ	MGP_BALBcJ_G0021322	protein coding gene	Chr14:48658994-48661351 (+)
C3H/HeJ	MGP_C3HHeJ_G0021102	protein coding gene	Chr14:50131157-50133514 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021760	protein coding gene	Chr14:52181471-52183828 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019307	protein coding gene	Chr14:47073472-47077254 (+)
CAST/EiJ	MGP_CASTEiJ_G0020621	protein coding gene	Chr14:46400295-46402667 (+)
CBA/J	MGP_CBAJ_G0021069	protein coding gene	Chr14:53746007-53748364 (+)
DBA/2J	MGP_DBA2J_G0021190	protein coding gene	Chr14:48423165-48425522 (+)
FVB/NJ	MGP_FVBNJ_G0021172	protein coding gene	Chr14:47871355-47873712 (+)
LP/J	MGP_LPJ_G0021264	protein coding gene	Chr14:50737925-50740282 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021196	protein coding gene	Chr14:53101428-53103785 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021787	protein coding gene	Chr14:49633924-49636281 (+)
PWK/PhJ	MGP_PWKPhJ_G0020368	protein coding gene	Chr14:44955752-44958109 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020196	protein coding gene	Chr14:45641749-45644118 (+)
WSB/EiJ	MGP_WSBEiJ_G0020674	protein coding gene	Chr14:49918869-49921224 (+)

Human Ortholog

TSSK4, testis specific serine kinase 4

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TSSK4, testis specific serine kinase 4
Synonyms

C14orf20, STK22E, TSK-4, TSK4, TSSK5
Links

HGNC:19825

NCBI Gene ID: 283629

neXtProt AC: NX_Q6SA08

UniProt: Q6SA08
Chr Location

14q12

MGI Vertebrate Homology

Tssk4 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TSSK4
Protein SuperFamily

Integrin-linked_kinase
Gene Tree

Tssk4

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

3
Genomic Mutations

1 involving Tssk4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced male fertility, decreased sperm ferility and abnormal axoneme structure and sperm midpiece morphology.

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All GO Annotations

54
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

62
RefSeq

14
UniProt

4
CCDS

CCDS56959.1, CCDS88669.1, CCDS88670.1

Ensembl

ENSMUSG00000007591 (Evidence)
NCBI Gene

71099

			Length	Strain/Species	Flank
genomic	ENSMUSG00000007591	Ensembl Gene Model \| MGI Sequence Detail	2356	C57BL/6J	± kb
transcript	ENSMUST00000228395	Ensembl \| MGI Sequence Detail	1273	Not Applicable
polypeptide	ENSMUSP00000154783	Ensembl \| MGI Sequence Detail	338	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016773 testis-specific serine/threonine-protein kinase 4

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR030616 Aurora kinase-like

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR047908 Testis-specific serine/threonine kinase 4, catalytic domain

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All nucleic 8

cDNA 8

Microarray probesets 2

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MGI:1923651

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 13

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tssk4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125798	Chr14:55887619-55887624 (+)	-19 bp
Tssr125799	Chr14:55887627-55887654 (+)	0 bp
Tssr125800	Chr14:55887658-55887683 (+)	30 bp
Tssr125801	Chr14:55887685-55887692 (+)	48 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24