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Fbxo24 Gene Detail
Summary
  • Symbol
    Fbxo24
  • Name
    F-box protein 24
  • Synonyms
    4933422D21Rik, Fbx24
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918426
    NCBI Gene: 71176
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137610767-137623340 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.59 cM, cytoband G1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    429 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918426
 protein coding gene Chr5:137610765-137627264 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030235
 protein coding gene Chr5:142388725-142406164 (-)
A/J MGP_AJ_G0030203
 protein coding gene Chr5:136177434-136194197 (-)
AKR/J MGP_AKRJ_G0030136
 protein coding gene Chr5:140607326-140623615 (-)
BALB/cJ MGP_BALBcJ_G0030213
 protein coding gene Chr5:137545786-137562375 (-)
C3H/HeJ MGP_C3HHeJ_G0029929
 protein coding gene Chr5:141257480-141276094 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030665
 protein coding gene Chr5:147644802-147665605 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027883
 protein coding gene Chr5:130420398-130437518 (-)
CAST/EiJ MGP_CASTEiJ_G0029339
 protein coding gene Chr5:140659625-140677303 (-)
CBA/J MGP_CBAJ_G0029899
 protein coding gene Chr5:153521515-153537860 (-)
DBA/2J MGP_DBA2J_G0030050
 protein coding gene Chr5:136078009-136095901 (-)
FVB/NJ MGP_FVBNJ_G0030005
 protein coding gene Chr5:135286588-135303476 (-)
LP/J MGP_LPJ_G0030139
 protein coding gene Chr5:142859642-142878358 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030037
 protein coding gene Chr5:156339885-156356655 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030706
 protein coding gene Chr5:140456953-140474397 (-)
PWK/PhJ MGP_PWKPhJ_G0029052
 protein coding gene Chr5:135169745-135186510 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028888
 protein coding gene Chr5:138017580-138038427 (-)
WSB/EiJ MGP_WSBEiJ_G0029412
 protein coding gene Chr5:141187875-141205446 (-)



Homology
more
  • Human Ortholog
    FBXO24, F-box protein 24
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FBXO24, F-box protein 24
  • Synonyms
    FBX24
  • Links
    NCBI Gene ID: 26261
    neXtProt AC: NX_O75426
    UniProt: O75426

  • Chr Location
    7q22.1; chr7:100583982-100601117 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display male infertility with oligoathenzoospermia, abnormal sperm heads, and abnormal sperm flagellum.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    5
  • cDNA Data
    2
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71176 NCBI Gene Model | MGI Sequence Detail 12574 C57BL/6J ±  kb
    transcript NM_027708 RefSeq | MGI Sequence Detail 2159 C57BL/6  
    polypeptide Q9D417 UniProt | EBI | MGI Sequence Detail 589 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 4
      Genomic 2
      cDNA 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Gene Ontology 1
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:358009 El-Mergawy R, et al., FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration. J Biol Chem. 2024 Jun;300(6):107359
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory