Aifm2 MGI Mouse Gene Detail - MGI:1918611 - apoptosis-inducing factor, mitochondrion-associated 2

Symbol

Aifm2
Name

apoptosis-inducing factor, mitochondrion-associated 2
Synonyms

5430437E11Rik, Amid, D730001I10Rik, PRG3

Feature Type

protein coding gene
IDs

MGI:1918611
NCBI Gene: 71361
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:61551042-61575039 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 32.27 cM
Mapping Data

2 experiments

SNPs within 2kb

680 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918611	protein coding gene	Chr10:61551042-61575474 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017287	protein coding gene	Chr10:61081620-61108146 (+)
A/J	MGP_AJ_G0017265	protein coding gene	Chr10:59244520-59268376 (+)
AKR/J	MGP_AKRJ_G0017225	protein coding gene	Chr10:60788734-60814466 (+)
BALB/cJ	MGP_BALBcJ_G0017225	protein coding gene	Chr10:59319481-59345052 (+)
C3H/HeJ	MGP_C3HHeJ_G0017048	protein coding gene	Chr10:60690904-60718481 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017683	protein coding gene	Chr10:63262483-63307967 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015374	protein coding gene	Chr10:56219332-56242151 (+)
CAST/EiJ	MGP_CASTEiJ_G0016619	protein coding gene	Chr10:60711185-60735742 (+)
CBA/J	MGP_CBAJ_G0017020	protein coding gene	Chr10:65624749-65650924 (+)
DBA/2J	MGP_DBA2J_G0017125	protein coding gene	Chr10:58515018-58539303 (+)
FVB/NJ	MGP_FVBNJ_G0017119	protein coding gene	Chr10:57766406-57791556 (+)
LP/J	MGP_LPJ_G0017200	protein coding gene	Chr10:61476431-61500328 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017147	protein coding gene	Chr10:67925374-67953867 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017721	protein coding gene	Chr10:60616157-60641576 (+)
PWK/PhJ	MGP_PWKPhJ_G0016402	protein coding gene	Chr10:58363168-58391890 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016185	protein coding gene	Chr10:59979170-60008501 (+)
WSB/EiJ	MGP_WSBEiJ_G0016683	protein coding gene	Chr10:60530579-60554393 (+)

Human Ortholog

AIFM2, AIF family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AIFM2, AIF family member 2
Synonyms

AMID, FSP1, PRG3
Links

HGNC:21411

NCBI Gene ID: 84883

neXtProt AC: NX_Q9BRQ8

UniProt: Q9BRQ8
Chr Location

10q22.1; chr10:70098223-70132934 (-) GRCh38

MGI Vertebrate Homology

Aifm2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AIFM2
Gene Tree

Aifm2

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

3
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Aifm2
Find Mice (IMSR)

20 strains or lines available

Homozygous null mice display reduced sensitivity to genotoxin induced cellular growth inhibition but have no change in spontaneous or induced tumor incidence.

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All GO Annotations

43
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

756
Tissues

30
cDNA Data

22
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase aifm2

ZFIN aifm2

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All Sequences

75
RefSeq

31
UniProt

1
CCDS

CCDS23884.1, CCDS48576.1

Ensembl

ENSMUSG00000020085 (Evidence)
NCBI Gene

71361

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020085	Ensembl Gene Model \| MGI Sequence Detail	23998	C57BL/6J	± kb
transcript	ENSMUST00000080099	Ensembl \| MGI Sequence Detail	1329	Not Applicable
polypeptide	ENSMUSP00000078998	Ensembl \| MGI Sequence Detail	380	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003869 ferroptosis suppressor protein 1

(term hierarchy)
EC

1.6.5.-
InterPro Domains

IPR023753 FAD/NAD(P)-binding domain

IPR036188 FAD/NAD(P)-binding domain superfamily

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All nucleic 22

cDNA 22

Microarray probesets 5

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MGI:1926110

Summaries

All 53

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 21
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Aifm2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93677	Chr10:61551059-61551107 (+)	41 bp
Tssr93678	Chr10:61556371-61556400 (+)	5,344 bp
Tssr93679	Chr10:61561926-61561938 (+)	10,890 bp
Tssr93680	Chr10:61561960-61561967 (+)	10,922 bp
Tssr93681	Chr10:61568918-61568936 (+)	17,885 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24