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Tmem74b Gene Detail
Summary
  • Symbol
    Tmem74b
  • Name
    transmembrane protein 74B
  • Synonyms
    5430405G05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918629
    NCBI Gene: 108832
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:151543928-151554077 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 74.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    315 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918629
 protein coding gene Chr2:151543294-151558665 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026644
 protein coding gene Chr2:156195185-156205467 (+)
A/J MGP_AJ_G0026610
 protein coding gene Chr2:149984226-149994373 (+)
AKR/J MGP_AKRJ_G0026580
 protein coding gene Chr2:154350962-154361099 (+)
BALB/cJ MGP_BALBcJ_G0026619
 protein coding gene Chr2:150294239-150304354 (+)
C3H/HeJ MGP_C3HHeJ_G0026362
 protein coding gene Chr2:154740923-154751036 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027068
 protein coding gene Chr2:160760758-160770887 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024439
 protein coding gene Chr2:143600266-143610522 (+)
CAST/EiJ MGP_CASTEiJ_G0025823
 protein coding gene Chr2:154968533-154978800 (+)
CBA/J MGP_CBAJ_G0026340
 protein coding gene Chr2:166631260-166641395 (+)
DBA/2J MGP_DBA2J_G0026476
 protein coding gene Chr2:149199056-149209199 (+)
FVB/NJ MGP_FVBNJ_G0026441
 protein coding gene Chr2:147643109-147653252 (+)
LP/J MGP_LPJ_G0026580
 protein coding gene Chr2:156366403-156376705 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026463
 protein coding gene Chr2:170797709-170807786 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027123
 protein coding gene Chr2:154233264-154243354 (+)
PWK/PhJ MGP_PWKPhJ_G0025557
 protein coding gene Chr2:148724797-148734997 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025360
 protein coding gene Chr2:153069018-153080521 (+)
WSB/EiJ MGP_WSBEiJ_G0025893
 protein coding gene Chr2:155144357-155155415 (+)



Homology
more
  • Human Ortholog
    TMEM74B, transmembrane protein 74B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM74B, transmembrane protein 74B
  • Synonyms
    C20orf46
  • Links
    NCBI Gene ID: 55321
    neXtProt AC: NX_Q9NUR3
    UniProt: Q9NUR3

  • Chr Location
    20p13; chr20:1180561-1189409 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Tmem74b
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    7 strains or lines available
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    9
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044364 Ensembl Gene Model | MGI Sequence Detail 10150 C57BL/6J ±  kb
transcript ENSMUST00000060196 Ensembl | MGI Sequence Detail 1435 Not Applicable  
polypeptide ENSMUSP00000060017 Ensembl | MGI Sequence Detail 232 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR029695 Transmembrane protein 74-like
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 2
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Phenotypes 7
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory