Gpatch8 MGI Mouse Gene Detail - MGI:1918667 - G patch domain containing 8

Symbol

Gpatch8
Name

G patch domain containing 8
Synonyms

5430405G24Rik, ENSMUSG00000075516, Fbm1, Gpatc8, mKIAA0553

Feature Type

protein coding gene
IDs

MGI:1918667
NCBI Gene: 237943
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:102366741-102447218 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 66.31 cM
Mapping Data

3 experiments

SNPs within 2kb

1351 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918667	protein coding gene	Chr11:102366737-102447218 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019238	protein coding gene	Chr11:105454176-105537833 (-)
A/J	MGP_AJ_G0019206	protein coding gene	Chr11:101003930-101087607 (-)
AKR/J	MGP_AKRJ_G0019175	protein coding gene	Chr11:104123232-104214441 (-)
BALB/cJ	MGP_BALBcJ_G0019180	protein coding gene	Chr11:101490407-101571660 (-)
C3H/HeJ	MGP_C3HHeJ_G0018989	protein coding gene	Chr11:104333481-104423538 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019629	protein coding gene	Chr11:108742452-108832833 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017255	protein coding gene	Chr11:98430284-98508693 (-)
CAST/EiJ	MGP_CASTEiJ_G0018543	protein coding gene	Chr11:105323147-105410650 (-)
CBA/J	MGP_CBAJ_G0018958	protein coding gene	Chr11:113231164-113320264 (-)
DBA/2J	MGP_DBA2J_G0019070	protein coding gene	Chr11:100522282-100602609 (-)
FVB/NJ	MGP_FVBNJ_G0019060	protein coding gene	Chr11:100052513-100139985 (-)
LP/J	MGP_LPJ_G0019139	protein coding gene	Chr11:105979646-106070963 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019091	protein coding gene	Chr11:112730390-112811963 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019667	protein coding gene	Chr11:104496461-104581402 (-)
PWK/PhJ	MGP_PWKPhJ_G0018306	protein coding gene	Chr11:101587314-101666892 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018098	protein coding gene	Chr11:104248979-104335666 (-)
WSB/EiJ	MGP_WSBEiJ_G0018592	protein coding gene	Chr11:104491558-104576812 (-)

Human Ortholog

GPATCH8, G-patch domain containing 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPATCH8, G-patch domain containing 8
Synonyms

GPATC8, KIAA0553
Links

HGNC:29066

NCBI Gene ID: 23131

neXtProt AC: NX_Q9UKJ3

UniProt: Q9UKJ3
Chr Location

17q21.31; chr17:44395281-44503430 (-) GRCh38

MGI Vertebrate Homology

Gpatch8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPATCH8
Gene Tree

Gpatch8

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Phenotype Summary

15 phenotype references

All Mutations and Alleles

64
Endonuclease-mediated

1
Gene trapped

61
Targeted

2
Genomic Mutations

1 involving Gpatch8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

74 strains or lines available

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All GO Annotations

4
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

11
cDNA Data

102
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpatch8

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All Sequences

90
RefSeq

41
UniProt

4
CCDS

CCDS48944.1

Ensembl

ENSMUSG00000034621 (Evidence)
NCBI Gene

237943

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034621	Ensembl Gene Model \| MGI Sequence Detail	80478	C57BL/6J	± kb
transcript	ENSMUST00000143842	Ensembl \| MGI Sequence Detail	6871	Not Applicable
polypeptide	ENSMUSP00000120649	Ensembl \| MGI Sequence Detail	1505	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000031762 G patch domain-containing protein 8

(term hierarchy)
InterPro Domains

IPR000467 G-patch domain

IPR052445 Zinc finger and G patch domain-containing protein

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

A2A6A1 4 sites, 1 O-linked glycan (4 sites)

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All nucleic 104

cDNA 104

Microarray probesets 10

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MGI:2144385, MGI:3642003, MGI:894666

Summaries

All 45

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 15
Earliest

J:41036 Kai N, et al., Molecular cloning of Fyn-associated molecules in the mouse central nervous system. J Neurosci Res. 1997 Jun 1;48(5):407-24
Latest

J:352160 Benbarche S, et al., GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies. Mol Cell. 2024 May 16;84(10):1886-1903.e10

TSS for Gpatch8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111095	Chr11:102446948-102446997 (-)	245 bp
Tssr111094	Chr11:102444048-102444052 (-)	3,168 bp
Tssr111093	Chr11:102443855-102443859 (-)	3,361 bp
Tssr111092	Chr11:102371908-102371923 (-)	75,302 bp
Tssr111091	Chr11:102371888-102371899 (-)	75,324 bp
Tssr111090	Chr11:102371600-102371614 (-)	75,611 bp
Tssr111089	Chr11:102369331-102369372 (-)	77,866 bp
Tssr111088	Chr11:102367406-102367413 (-)	79,808 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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