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Arhgap21 Gene Detail
Summary
  • Symbol
    Arhgap21
  • Name
    Rho GTPase activating protein 21
  • Synonyms
    5530401C11Rik, ARHGAP10
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918685
    NCBI Gene: 71435
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:20852730-20973692 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 14.60 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3636 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918685
 protein coding gene Chr2:20852730-20973761 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025386
 protein coding gene Chr2:18629877-18757987 (-)
A/J MGP_AJ_G0025364
 protein coding gene Chr2:17886567-18009815 (-)
AKR/J MGP_AKRJ_G0025332
 protein coding gene Chr2:18529366-18652429 (-)
BALB/cJ MGP_BALBcJ_G0025359
 protein coding gene Chr2:17939774-18061330 (-)
C3H/HeJ MGP_C3HHeJ_G0025119
 protein coding gene Chr2:18402444-18525696 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025802
 protein coding gene Chr2:19174801-19300616 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023217
 protein coding gene Chr2:17185524-17311335 (-)
CAST/EiJ MGP_CASTEiJ_G0024583
 protein coding gene Chr2:18366559-18491765 (-)
CBA/J MGP_CBAJ_G0025098
 protein coding gene Chr2:19948712-20076348 (-)
DBA/2J MGP_DBA2J_G0025230
 protein coding gene Chr2:17806176-17929998 (-)
FVB/NJ MGP_FVBNJ_G0025193
 protein coding gene Chr2:17600830-17721978 (-)
LP/J MGP_LPJ_G0025317
 protein coding gene Chr2:18475184-18597074 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025224
 protein coding gene Chr2:19901184-20028424 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025860
 protein coding gene Chr2:18423835-18547109 (-)
PWK/PhJ MGP_PWKPhJ_G0024332
 protein coding gene Chr2:17660438-17783434 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024132
 protein coding gene Chr2:18625200-18746640 (-)
WSB/EiJ MGP_WSBEiJ_G0024653
 protein coding gene Chr2:18501687-18623534 (-)



Homology
more
  • Human Ortholog
    ARHGAP21, Rho GTPase activating protein 21
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP21, Rho GTPase activating protein 21
  • Synonyms
    ARHGAP10
  • Links
    NCBI Gene ID: 57584
    neXtProt AC: NX_Q5T5U3
    UniProt: Q5T5U3

  • Chr Location
    10p12.1; chr10:24583609-24723887 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit die by E8. Mice heterozygous for the allele exhibit enhanced egress of HSC from the bone marrow resulting in decreased red blood cells, hemoglobin and platelets but increased leukocytes and neutrophils.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    751
  • Tissues
    10
  • cDNA Data
    8
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036591 Ensembl Gene Model | MGI Sequence Detail 120963 C57BL/6J ±  kb
    transcript ENSMUST00000154230 Ensembl | MGI Sequence Detail 6972 Not Applicable  
    polypeptide ENSMUSP00000122497 Ensembl | MGI Sequence Detail 1955 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138776
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory