Ppp6r2 MGI Mouse Gene Detail - MGI:1918724 - protein phosphatase 6, regulatory subunit 2

Symbol

Ppp6r2
Name

protein phosphatase 6, regulatory subunit 2
Synonyms

1110033O10Rik, 8430411H09Rik, B230107H12Rik, Pp6r2, Saps2

Feature Type

protein coding gene
IDs

MGI:1918724
NCBI Gene: 71474
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr15:89095756-89171213 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 44.76 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

1675 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918724	protein coding gene	Chr15:89095654-89171218 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022223	protein coding gene	Chr15:90390584-90471254 (+)
A/J	MGP_AJ_G0022182	protein coding gene	Chr15:86936254-87010704 (+)
AKR/J	MGP_AKRJ_G0022157	protein coding gene	Chr15:89539060-89585540 (+)
BALB/cJ	MGP_BALBcJ_G0022188	protein coding gene	Chr15:87037987-87117359 (+)
C3H/HeJ	MGP_C3HHeJ_G0021958	protein coding gene	Chr15:89495690-89579650 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022633	protein coding gene	Chr15:93717533-93764152 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020158	protein coding gene	Chr15:83187690-83232326 (+)
CAST/EiJ	MGP_CASTEiJ_G0021480	protein coding gene	Chr15:90280020-90356146 (+)
CBA/J	MGP_CBAJ_G0021925	protein coding gene	Chr15:96840146-96935577 (+)
DBA/2J	MGP_DBA2J_G0022052	protein coding gene	Chr15:86416343-86463200 (+)
FVB/NJ	MGP_FVBNJ_G0022031	protein coding gene	Chr15:85453439-85529849 (+)
LP/J	MGP_LPJ_G0022123	protein coding gene	Chr15:90545280-90632539 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022051	protein coding gene	Chr15:101261752-101339275 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022648	protein coding gene	Chr15:89543577-89626144 (+)
PWK/PhJ	MGP_PWKPhJ_G0021221	protein coding gene	Chr15:86448312-86523855 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021055	protein coding gene	Chr15:89275741-89362848 (+)
WSB/EiJ	MGP_WSBEiJ_G0021529	protein coding gene	Chr15:90029367-90109929 (+)

Human Ortholog

PPP6R2, protein phosphatase 6 regulatory subunit 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP6R2, protein phosphatase 6 regulatory subunit 2
Synonyms

KIAA0685, PP6R2, SAP190, SAPS2
Links

HGNC:19253

NCBI Gene ID: 9701

neXtProt AC: NX_O75170

UniProt: O75170
Chr Location

22q13.33; chr22:50330774-50445090 (+) GRCh38

MGI Vertebrate Homology

Ppp6r2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PPP6R2
Gene Tree

Ppp6r2

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Gene trapped

1
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Ppp6r2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

909
Tissues

75
cDNA Data

11
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppp6r2

ZFIN ppp6r2a

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All Sequences

134
RefSeq

80
UniProt

9
CCDS

CCDS27743.1

Ensembl

ENSMUSG00000036561 (Evidence)
NCBI Gene

71474

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036561	Ensembl Gene Model \| MGI Sequence Detail	75458	C57BL/6J	± kb
transcript	ENSMUST00000238818	Ensembl \| MGI Sequence Detail	3378	Not Applicable
polypeptide	ENSMUSP00000159040	Ensembl \| MGI Sequence Detail	950	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000014452 serine/threonine-protein phosphatase 6 regulatory subunit 2

(term hierarchy)
InterPro Domains

IPR016024 Armadillo-type fold

IPR006588 Peptide N glycanase, PAW domain

IPR007587 SIT4 phosphatase-associated protein family
GlyGen

Q8R3Q2 1 site, 1 O-linked glycan (1 site)

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All nucleic 13

cDNA 13

Microarray probesets 3

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MGI:1915948, MGI:1925851

Summaries

All 53

Developmental Gene Expression 6

Diseases 1

Gene Ontology 4

Phenotypes 26
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ppp6r2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132647	Chr15:89095725-89095809 (+)	11 bp
Tssr132648	Chr15:89095810-89095823 (+)	61 bp
Tssr132649	Chr15:89096512-89096514 (+)	757 bp
Tssr132650	Chr15:89127518-89127533 (+)	31,770 bp
Tssr132651	Chr15:89127534-89127569 (+)	31,796 bp
Tssr132652	Chr15:89170753-89170754 (+)	74,998 bp
Tssr132653	Chr15:89171156-89171160 (+)	75,402 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24