Grap MGI Mouse Gene Detail - MGI:1918770 - GRB2-related adaptor protein

Symbol

Grap
Name

GRB2-related adaptor protein
Synonyms

8430435N19Rik

Feature Type

protein coding gene
IDs

MGI:1918770
NCBI Gene: 71520
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:61544091-61563610 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.96 cM, cytoband B2
Mapping Data

3 experiments

SNPs within 2kb

648 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918770	protein coding gene	Chr11:61544081-61563610 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018443	protein coding gene	Chr11:61626304-61645368 (+)
A/J	MGP_AJ_G0018412	protein coding gene	Chr11:59352950-59372418 (+)
AKR/J	MGP_AKRJ_G0018382	protein coding gene	Chr11:61194746-61213649 (+)
BALB/cJ	MGP_BALBcJ_G0018383	protein coding gene	Chr11:59654457-59674712 (+)
C3H/HeJ	MGP_C3HHeJ_G0018196	protein coding gene	Chr11:61177611-61199296 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018835	protein coding gene	Chr11:63582531-63606779 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016481	protein coding gene	Chr11:56469299-56488537 (+)
CAST/EiJ	MGP_CASTEiJ_G0017753	protein coding gene	Chr11:61284139-61303467 (+)
CBA/J	MGP_CBAJ_G0018170	protein coding gene	Chr11:66340539-66367220 (+)
DBA/2J	MGP_DBA2J_G0018279	protein coding gene	Chr11:58921503-58941442 (+)
FVB/NJ	MGP_FVBNJ_G0018270	protein coding gene	Chr11:58606343-58625564 (+)
LP/J	MGP_LPJ_G0018352	protein coding gene	Chr11:62198892-62217972 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018294	protein coding gene	Chr11:67340267-67359171 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018876	protein coding gene	Chr11:61331121-61351827 (+)
PWK/PhJ	MGP_PWKPhJ_G0017526	protein coding gene	Chr11:59527586-59547115 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017316	protein coding gene	Chr11:61158470-61178376 (+)
WSB/EiJ	MGP_WSBEiJ_G0017805	protein coding gene	Chr11:60940634-60959608 (+)

Human Ortholog

GRAP, GRB2 related adaptor protein

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRAP, GRB2 related adaptor protein
Synonyms

DFNB114
Links

HGNC:4562

NCBI Gene ID: 10750

neXtProt AC: NX_Q13588

UniProt: Q13588
Chr Location

17p11.2; chr17:19020656-19051373 (-) GRCh38

Human Ortholog

GRAPL, GRB2 related adaptor protein like
Synonyms

GRAPLDR
Links

HGNC:37240

NCBI Gene ID: 400581

neXtProt AC: NX_Q8TC17

UniProt: Q8TC17
Chr Location

17p11.2

MGI Vertebrate Homology

Grap stringent orthology
2 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GRAP, GRAPL
Gene Tree

Grap

Diseases

1 with human GRAP associations

				Human Disease	Mouse Models
				autosomal recessive nonsyndromic deafness 114 IDs autosomal recessive nonsyndromic deafness 114 DOID:0111642 OMIM:618456

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

3
Genomic Mutations

1 involving Grap
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available

Mice homozygous for disruptions in this gene display a greater proliferative T cell response to TCR stimulation. In all other respects, they are normal.

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All GO Annotations

11
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

9
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase grap

ZFIN grapa, grapb

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All Sequences

34
RefSeq

4
UniProt

1
CCDS

CCDS24817.1

Ensembl

ENSMUSG00000004837 (Evidence)
NCBI Gene

71520

			Length	Strain/Species	Flank
genomic	ENSMUSG00000004837	Ensembl Gene Model \| MGI Sequence Detail	19520	C57BL/6J	± kb
transcript	ENSMUST00000004959	Ensembl \| MGI Sequence Detail	1662	Not Applicable
polypeptide	ENSMUSP00000004959	Ensembl \| MGI Sequence Detail	217	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008219 GRB2-related adapter protein

(term hierarchy)
InterPro Domains

IPR035645 GRAP, N-terminal SH3 domain

IPR043539 Grb2-like

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

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All nucleic 16

Genomic 2

cDNA 13

Primer pair 1

Microarray probesets 2

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MGI:2144614

Summaries

All 31

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 8
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:273017 Li C, et al., Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss. Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1347-1352

TSS for Grap:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101972	Chr11:61544050-61544061 (+)	-35 bp
Tssr101973	Chr11:61544070-61544079 (+)	-16 bp
Tssr101974	Chr11:61544085-61544179 (+)	41 bp
Tssr101975	Chr11:61544184-61544196 (+)	99 bp
Tssr101976	Chr11:61547155-61547159 (+)	3,066 bp
Tssr101977	Chr11:61551872-61551876 (+)	7,783 bp
Tssr101978	Chr11:61559854-61559859 (+)	15,766 bp
Tssr101979	Chr11:61563021-61563044 (+)	18,942 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24