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Pds5a Gene Detail
Summary
  • Symbol
    Pds5a
  • Name
    PDS5 cohesin associated factor A
  • Synonyms
    9030416H16Rik, E230024D05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918771
    NCBI Gene: 71521
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:65763062-65855579 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 33.76 cM, cytoband C3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1847 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918771
 protein coding gene Chr5:65763062-65855616 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029582
 protein coding gene Chr5:65264961-65387009 (-)
A/J MGP_AJ_G0029550
 protein coding gene Chr5:62830324-62922807 (-)
AKR/J MGP_AKRJ_G0029498
 protein coding gene Chr5:64829873-64934528 (-)
BALB/cJ MGP_BALBcJ_G0029559
 protein coding gene Chr5:63520314-63616658 (-)
C3H/HeJ MGP_C3HHeJ_G0029282
 protein coding gene Chr5:65169131-65272065 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030013
 protein coding gene Chr5:67954563-68061334 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027253
 protein coding gene Chr5:58904781-58996385 (-)
CAST/EiJ MGP_CASTEiJ_G0028690
 protein coding gene Chr5:64270386-64368987 (-)
CBA/J MGP_CBAJ_G0029251
 protein coding gene Chr5:70162945-70270912 (-)
DBA/2J MGP_DBA2J_G0029397
 protein coding gene Chr5:62868667-62965082 (-)
FVB/NJ MGP_FVBNJ_G0029357
 protein coding gene Chr5:62037091-62131130 (-)
LP/J MGP_LPJ_G0029482
 protein coding gene Chr5:65770393-65872226 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029385
 protein coding gene Chr5:73030772-73135968 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030046
 protein coding gene Chr5:64500614-64597685 (-)
PWK/PhJ MGP_PWKPhJ_G0028414
 protein coding gene Chr5:61842431-61934157 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028248
 protein coding gene Chr5:63836907-63938081 (-)
WSB/EiJ MGP_WSBEiJ_G0028770
 protein coding gene Chr5:64708915-64810312 (-)



Homology
more
  • Human Ortholog
    PDS5A, PDS5 cohesin associated factor A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDS5A, PDS5 cohesin associated factor A
  • Synonyms
    PIG54, SCC-112, SCC112
  • Links
    NCBI Gene ID: 23244
    neXtProt AC: NX_Q29RF7
    UniProt: Q29RF7

  • Chr Location
    4p14; chr4:39822863-39977956 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pds5a mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotypes from multigenic genotypes
    3 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neonatal lethality associated with respiratory distress, abnormal heart development, abnormal skeletal development, kidney agenesis, and delayed enteric nervous system development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    990
  • Tissues
    108
  • cDNA Data
    7
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71521 NCBI Gene Model | MGI Sequence Detail 92518 C57BL/6J ±  kb
    transcript NM_001081321 RefSeq | MGI Sequence Detail 8999 ZRU/MplStud  
    polypeptide Q6A026 UniProt | EBI | MGI Sequence Detail 1332 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2442025
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 28
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:292628 Viera A, et al., PDS5 proteins regulate the length of axial elements and telomere integrity during male mouse meiosis. EMBO Rep. 2020 Jun 4;21(6):e49273
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory