Gas2l3 MGI Mouse Gene Detail - MGI:1918780 - growth arrest-specific 2 like 3

Symbol

Gas2l3
Name

growth arrest-specific 2 like 3
Synonyms

8430435B07Rik, LOC237436

Feature Type

protein coding gene
IDs

MGI:1918780
NCBI Gene: 237436
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr10:89244685-89279829 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 44.98 cM
Mapping Data

3 experiments

SNPs within 2kb

1077 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918780	protein coding gene	Chr10:89244684-89279935 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017635	protein coding gene	Chr10:90567699-90610884 (-)
A/J	MGP_AJ_G0017614	protein coding gene	Chr10:87479118-87513957 (-)
AKR/J	MGP_AKRJ_G0017572	protein coding gene	Chr10:89971406-90008253 (-)
BALB/cJ	MGP_BALBcJ_G0017577	protein coding gene	Chr10:87750958-87785571 (-)
C3H/HeJ	MGP_C3HHeJ_G0017400	protein coding gene	Chr10:89976567-90015655 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018034	protein coding gene	Chr10:93607553-93650425 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015716	protein coding gene	Chr10:83206179-83241517 (-)
CAST/EiJ	MGP_CASTEiJ_G0016965	protein coding gene	Chr10:89892574-89930197 (-)
CBA/J	MGP_CBAJ_G0017369	protein coding gene	Chr10:97474951-97511925 (-)
DBA/2J	MGP_DBA2J_G0017475	protein coding gene	Chr10:86615703-86651011 (-)
FVB/NJ	MGP_FVBNJ_G0017467	protein coding gene	Chr10:85817237-85851934 (-)
LP/J	MGP_LPJ_G0017549	protein coding gene	Chr10:91225003-91262989 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017498	protein coding gene	Chr10:98958474-98997096 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018071	protein coding gene	Chr10:89843108-89879158 (-)
PWK/PhJ	MGP_PWKPhJ_G0016746	protein coding gene	Chr10:86637259-86674439 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016534	protein coding gene	Chr10:88621749-88658524 (-)
WSB/EiJ	MGP_WSBEiJ_G0017024	protein coding gene	Chr10:89848011-89885940 (-)

Human Ortholog

GAS2L3, growth arrest specific 2 like 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GAS2L3, growth arrest specific 2 like 3
Synonyms

G2L3
Links

HGNC:27475

NCBI Gene ID: 283431

neXtProt AC: NX_Q86XJ1

UniProt: Q86XJ1
Chr Location

12q23.1; chr12:100573683-100628288 (+) GRCh38

MGI Vertebrate Homology

Gas2l3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GAS2L3
Gene Tree

Gas2l3

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Phenotype Summary

19 phenotypes from 2 alleles in 3 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

1
Gene trapped

19
Targeted

4
Transposon induced

1
Genomic Mutations

2 involving Gas2l3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

72 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display partial postnatal lethality with none surviving past 4 months, dilated cardiomyopathy, cardiac interstitial fibrosis, and premature binucleation of cardiomyocytes.

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

5
cDNA Data

54
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gas2l3

ZFIN gas2l3

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All Sequences

68
RefSeq

8
UniProt

6
CCDS

CCDS24115.1, CCDS88068.1

Ensembl

ENSMUSG00000074802 (Evidence)
NCBI Gene

237436

			Length	Strain/Species	Flank
genomic	ENSMUSG00000074802	Ensembl Gene Model \| MGI Sequence Detail	35145	C57BL/6J	± kb
transcript	ENSMUST00000105298	Ensembl \| MGI Sequence Detail	6305	Not Applicable
polypeptide	ENSMUSP00000100935	Ensembl \| MGI Sequence Detail	683	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007852 GAS2-like protein 3

(term hierarchy)
InterPro Domains

IPR001715 Calponin homology domain

IPR036872 CH domain superfamily

IPR003108 GAR domain

IPR036534 GAR domain superfamily

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All nucleic 55

cDNA 54

Primer pair 1

Microarray probesets 5

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MGI:2685086

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 11
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:290729 Grundl M, et al., Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes. PLoS Genet. 2020 May;16(5):e1008818

TSS for Gas2l3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98872	Chr10:89279750-89279824 (-)	42 bp
Tssr98871	Chr10:89270750-89270756 (-)	9,076 bp
Tssr98870	Chr10:89270527-89270567 (-)	9,282 bp
Tssr98869	Chr10:89270510-89270521 (-)	9,313 bp
Tssr98868	Chr10:89269916-89269953 (-)	9,894 bp
Tssr98867	Chr10:89253571-89253575 (-)	26,256 bp
Tssr98866	Chr10:89246700-89246713 (-)	33,122 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24