Isx MGI Mouse Gene Detail - MGI:1918847 - intestine specific homeobox

Symbol

Isx
Name

intestine specific homeobox
Synonyms

9130012O13Rik

Feature Type

protein coding gene
IDs

MGI:1918847
NCBI Gene: 71597
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr8:75599801-75620134 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 35.54 cM, cytoband C2
Mapping Data

2 experiments

SNPs within 2kb

587 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918847	protein coding gene	Chr8:75599326-75620134 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033792	protein coding gene	Chr8:75305944-75326314 (+)
A/J	MGP_AJ_G0033774	protein coding gene	Chr8:72354253-72373968 (+)
AKR/J	MGP_AKRJ_G0033701	protein coding gene	Chr8:74559747-74581333 (+)
BALB/cJ	MGP_BALBcJ_G0033768	protein coding gene	Chr8:72447202-72470187 (+)
C3H/HeJ	MGP_C3HHeJ_G0033477	protein coding gene	Chr8:75115646-75137072 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034288	protein coding gene	Chr8:78237964-78261732 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031229	protein coding gene	Chr8:66626829-66646377 (+)
CAST/EiJ	MGP_CASTEiJ_G0032806	protein coding gene	Chr8:74399574-74421252 (+)
CBA/J	MGP_CBAJ_G0033456	protein coding gene	Chr8:80982509-81005833 (+)
DBA/2J	MGP_DBA2J_G0033610	protein coding gene	Chr8:72033605-72057010 (+)
FVB/NJ	MGP_FVBNJ_G0033555	protein coding gene	Chr8:71122473-71142485 (+)
LP/J	MGP_LPJ_G0033699	protein coding gene	Chr8:75442937-75463744 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033598	protein coding gene	Chr8:83557445-83577461 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034305	protein coding gene	Chr8:74530857-74551581 (+)
PWK/PhJ	MGP_PWKPhJ_G0032512	protein coding gene	Chr8:71303976-71325323 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032350	protein coding gene	Chr8:73405003-73425095 (+)
WSB/EiJ	MGP_WSBEiJ_G0032921	protein coding gene	Chr8:74829050-74850798 (+)

Human Ortholog

ISX, intestine specific homeobox

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ISX, intestine specific homeobox
Synonyms

Pix-1, RAXLX
Links

HGNC:28084

NCBI Gene ID: 91464

neXtProt AC: NX_Q2M1V0

UniProt: Q2M1V0
Chr Location

22q12.3; chr22:35066136-35087387 (+) GRCh38

MGI Vertebrate Homology

Isx stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ISX
Gene Tree

Isx

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

4
Transgenic

1
Genomic Mutations

1 involving Isx
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available

Homozygous null mice are viable and fertile up to 1 year of age and display no histological abnormalities of the gut.

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

895
Tissues

126
cDNA Data

10
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ISX

Xenbase isx

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All Sequences

34
RefSeq

4
UniProt

2
CCDS

CCDS40391.1, CCDS80899.1

Ensembl

ENSMUSG00000031621 (Evidence)
NCBI Gene

71597

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031621	Ensembl Gene Model \| MGI Sequence Detail	20334	C57BL/6J	± kb
transcript	ENSMUST00000174427	Ensembl \| MGI Sequence Detail	1026	Not Applicable
polypeptide	ENSMUSP00000134368	Ensembl \| MGI Sequence Detail	242	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009120 intestine-specific homeobox

(term hierarchy)
InterPro Domains

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR009057 Homeobox-like domain superfamily

IPR050649 Paired Homeobox Transcription Factors

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All nucleic 14

cDNA 10

Primer pair 2

Other 2

Microarray probesets 2

Summaries

All 40

Developmental Gene Expression 10

Gene Ontology 5

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:353895 Thomas LD, et al., Genetic deletion of Bco2 and Isx establishes a golden mouse model for carotenoid research. Mol Metab. 2023 May 22;73:101742

TSS for Isx:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78023	Chr8:75599320-75599368 (+)	-457 bp
Tssr78024	Chr8:75599379-75599391 (+)	-416 bp
Tssr78025	Chr8:75599755-75599765 (+)	-41 bp
Tssr78026	Chr8:75599824-75599856 (+)	39 bp
Tssr78027	Chr8:75599898-75599911 (+)	104 bp
Tssr78028	Chr8:75599919-75599931 (+)	124 bp
Tssr78029	Chr8:75600221-75600243 (+)	431 bp
Tssr78030	Chr8:75602976-75602980 (+)	3,177 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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