Gimap6 MGI Mouse Gene Detail - MGI:1918876 - GTPase, IMAP family member 6

Symbol

Gimap6
Name

GTPase, IMAP family member 6
Synonyms

4833419H03Rik, Ian6

Feature Type

protein coding gene
IDs

MGI:1918876
NCBI Gene: 231931
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr6:48678516-48685159 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 23.67 cM
Mapping Data

1 experiment

SNPs within 2kb

226 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918876	protein coding gene	Chr6:48678516-48685178 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030707	protein coding gene	Chr6:47657412-47664055 (-)
A/J	MGP_AJ_G0030678	protein coding gene	Chr6:45492444-45499107 (-)
AKR/J	MGP_AKRJ_G0030603	protein coding gene	Chr6:47091967-47098600 (-)
BALB/cJ	MGP_BALBcJ_G0030688	protein coding gene	Chr6:45825042-45831674 (-)
C3H/HeJ	MGP_C3HHeJ_G0030401	protein coding gene	Chr6:47094572-47101204 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031143	protein coding gene	Chr6:48778624-48785540 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028350	protein coding gene	Chr6:43120894-43127398 (-)
CAST/EiJ	MGP_CASTEiJ_G0029805	protein coding gene	Chr6:46821979-46829257 (-)
CBA/J	MGP_CBAJ_G0030376	protein coding gene	Chr6:50798785-50805405 (-)
DBA/2J	MGP_DBA2J_G0030525	protein coding gene	Chr6:45409763-45416385 (-)
FVB/NJ	MGP_FVBNJ_G0030477	protein coding gene	Chr6:45041864-45048496 (-)
LP/J	MGP_LPJ_G0030610	protein coding gene	Chr6:47636832-47643479 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030511	protein coding gene	Chr6:53609735-53617391 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031172	protein coding gene	Chr6:46958124-46964767 (-)
PWK/PhJ	MGP_PWKPhJ_G0029517	protein coding gene	Chr6:44942000-44948644 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029353	protein coding gene	Chr6:46304867-46311495 (-)
WSB/EiJ	MGP_WSBEiJ_G0029882	protein coding gene	Chr6:46957443-46964078 (-)

Human Ortholog

GIMAP6, GTPase, IMAP family member 6

Vertebrate Orthologs

10

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GIMAP6, GTPase, IMAP family member 6
Synonyms

IAN-2, IAN2, IAN-6, IAN6
Links

HGNC:21918

NCBI Gene ID: 474344

neXtProt AC: NX_Q6P9H5

UniProt: Q6P9H5
Chr Location

7q36.1; chr7:150625375-150632648 (-) GRCh38

MGI Vertebrate Homology

Gimap6 stringent orthology
1 human;1 mouse;1 rat;8 zebrafish
HCOP

vertebrate homology predictions: GIMAP6
Gene Tree

Gimap6

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Phenotype Summary

31 phenotypes from 3 alleles in 3 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Conditional homozygous knockout in lymphocytes affects autophagy and mitophagy in peripheral T cells and increases apoptosis and decreases the numbers of these T cells.

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All GO Annotations

4
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

738
Tissues

21
cDNA Data

82
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

2
UniProt

3
CCDS

CCDS20111.1

Ensembl

ENSMUSG00000047867 (Evidence)
NCBI Gene

231931

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047867	Ensembl Gene Model \| MGI Sequence Detail	6644	C57BL/6J	± kb
transcript	ENSMUST00000053661	Ensembl \| MGI Sequence Detail	1594	Not Applicable
polypeptide	ENSMUSP00000059371	Ensembl \| MGI Sequence Detail	305	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032526 GTPase IMAP family member 6

(term hierarchy)
InterPro Domains

IPR006703 AIG1-type guanine nucleotide-binding (G) domain

IPR045058 GTPase GIMA/IAN/Toc

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 84

cDNA 84

Microarray probesets 3

Summaries

All 35

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gimap6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr60757	Chr6:48685798-48685832 (-)	-656 bp
Tssr60756	Chr6:48685197-48685208 (-)	-44 bp
Tssr60755	Chr6:48685140-48685186 (-)	-4 bp
Tssr60754	Chr6:48685108-48685137 (-)	36 bp
Tssr60753	Chr6:48685063-48685093 (-)	81 bp
Tssr60752	Chr6:48684552-48684568 (-)	599 bp
Tssr60751	Chr6:48678892-48678897 (-)	6,264 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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