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Gimap6 Gene Detail
Summary
  • Symbol
    Gimap6
  • Name
    GTPase, IMAP family member 6
  • Synonyms
    4833419H03Rik, Ian6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918876
    NCBI Gene: 231931
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:48678516-48685159 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 23.67 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    226 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918876
 protein coding gene Chr6:48678516-48685178 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030707
 protein coding gene Chr6:47657412-47664055 (-)
A/J MGP_AJ_G0030678
 protein coding gene Chr6:45492444-45499107 (-)
AKR/J MGP_AKRJ_G0030603
 protein coding gene Chr6:47091967-47098600 (-)
BALB/cJ MGP_BALBcJ_G0030688
 protein coding gene Chr6:45825042-45831674 (-)
C3H/HeJ MGP_C3HHeJ_G0030401
 protein coding gene Chr6:47094572-47101204 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031143
 protein coding gene Chr6:48778624-48785540 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028350
 protein coding gene Chr6:43120894-43127398 (-)
CAST/EiJ MGP_CASTEiJ_G0029805
 protein coding gene Chr6:46821979-46829257 (-)
CBA/J MGP_CBAJ_G0030376
 protein coding gene Chr6:50798785-50805405 (-)
DBA/2J MGP_DBA2J_G0030525
 protein coding gene Chr6:45409763-45416385 (-)
FVB/NJ MGP_FVBNJ_G0030477
 protein coding gene Chr6:45041864-45048496 (-)
LP/J MGP_LPJ_G0030610
 protein coding gene Chr6:47636832-47643479 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030511
 protein coding gene Chr6:53609735-53617391 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031172
 protein coding gene Chr6:46958124-46964767 (-)
PWK/PhJ MGP_PWKPhJ_G0029517
 protein coding gene Chr6:44942000-44948644 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029353
 protein coding gene Chr6:46304867-46311495 (-)
WSB/EiJ MGP_WSBEiJ_G0029882
 protein coding gene Chr6:46957443-46964078 (-)



Homology
more
  • Human Ortholog
    GIMAP6, GTPase, IMAP family member 6
  • Vertebrate Orthologs
    10
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GIMAP6, GTPase, IMAP family member 6
  • Synonyms
    IAN-2, IAN2, IAN-6, IAN6
  • Links
    NCBI Gene ID: 474344
    neXtProt AC: NX_Q6P9H5
    UniProt: Q6P9H5

  • Chr Location
    7q36.1; chr7:150625375-150632648 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Conditional homozygous knockout in lymphocytes affects autophagy and mitophagy in peripheral T cells and increases apoptosis and decreases the numbers of these T cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    21
  • cDNA Data
    82
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047867 Ensembl Gene Model | MGI Sequence Detail 6644 C57BL/6J ±  kb
    transcript ENSMUST00000053661 Ensembl | MGI Sequence Detail 1594 Not Applicable  
    polypeptide ENSMUSP00000059371 Ensembl | MGI Sequence Detail 305 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      cDNA 84

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory