Zfp949 MGI Mouse Gene Detail - MGI:1918890

Symbol

Zfp949
Name

zinc finger protein 949
Synonyms

4930422I07Rik, Nczf

Feature Type

protein coding gene
IDs

MGI:1918890
NCBI Gene: 71640
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:88430073-88453114 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 47.24 cM, cytoband E3.2
Mapping Data

3 experiments

SNPs within 2kb

461 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918890	protein coding gene	Chr9:88430073-88453139 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035110	protein coding gene	Chr9:89428698-89454362 (+)
A/J	MGP_AJ_G0035091	protein coding gene	Chr9:86311229-86334802 (+)
AKR/J	MGP_AKRJ_G0035019	protein coding gene	Chr9:88340789-88377675 (+)
BALB/cJ	MGP_BALBcJ_G0035079	protein coding gene	Chr9:85924337-85951672 (+)
C3H/HeJ	MGP_C3HHeJ_G0034791	protein coding gene	Chr9:88802535-88830782 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035603	protein coding gene	Chr9:91851558-91876442 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032509	protein coding gene	Chr9:85005415-85012153 (+)
CAST/EiJ	MGP_CASTEiJ_G0034109	protein coding gene	Chr9:89257089-89283659 (+)
CBA/J	MGP_CBAJ_G0034764	protein coding gene	Chr9:95067392-95101705 (+)
DBA/2J	MGP_DBA2J_G0034922	protein coding gene	Chr9:85835009-85868199 (+)
FVB/NJ	MGP_FVBNJ_G0034865	protein coding gene	Chr9:84887512-84911511 (+)
LP/J	MGP_LPJ_G0035003	protein coding gene	Chr9:89631096-89664280 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034907	protein coding gene	Chr9:96702360-96732549 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035623	protein coding gene	Chr9:88465959-88492777 (+)
PWK/PhJ	MGP_PWKPhJ_G0033813	protein coding gene	Chr9:85992832-86017233 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033649	protein coding gene	Chr9:88651038-88675863 (+)
WSB/EiJ	MGP_WSBEiJ_G0034226	protein coding gene	Chr9:88505702-88531402 (+)

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MGI Vertebrate Homology

Zfp949 stringent orthology
1 mouse;1 rat
Gene Tree

Zfp949

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
4 phenotypes from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Gene trapped

5
Targeted

1
Genomic Mutations

1 involving Zfp949
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit embryonic lethality during organogenesis with defects in growth, development, cell proliferation, apoptosis and turning.

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All GO Annotations

4
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

9
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

65
RefSeq

22
UniProt

4
CCDS

CCDS52880.1

Ensembl

ENSMUSG00000032425 (Evidence)
NCBI Gene

71640

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032425	Ensembl Gene Model \| MGI Sequence Detail	23042	C57BL/6J	± kb
transcript	ENSMUST00000162827	Ensembl \| MGI Sequence Detail	3472	Not Applicable
polypeptide	ENSMUSP00000125325	Ensembl \| MGI Sequence Detail	603	Not Applicable

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UniProt

4 Sequences
InterPro Domains

IPR036051 KRAB domain superfamily

IPR001909 Krueppel-associated box

IPR050169 Krueppel C2H2-type zinc-finger

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

E9Q732 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 5

Summaries

All 27

Developmental Gene Expression 1

Gene Ontology 1

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:259302 Teratake Y, et al., Transcriptional repression of p27 is essential for murine embryonic development. Sci Rep. 2016 May 19;6:26244

TSS for Zfp949:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86413	Chr9:88430066-88430176 (+)	48 bp
Tssr86414	Chr9:88431915-88431917 (+)	1,843 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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