Shtn1 MGI Mouse Gene Detail - MGI:1918903

Symbol

Shtn1
Name

shootin 1
Synonyms

4930506M07Rik, shootin1

Feature Type

protein coding gene
IDs

MGI:1918903
NCBI Gene: 71653
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr19:58961788-59064532 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 54.56 cM
Mapping Data

2 experiments

SNPs within 2kb

2511 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918903	protein coding gene	Chr19:58961788-59064536 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025284	protein coding gene	Chr19:59471624-59579615 (-)
A/J	MGP_AJ_G0025260	protein coding gene	Chr19:56562882-56665067 (-)
AKR/J	MGP_AKRJ_G0025229	protein coding gene	Chr19:58327000-58432086 (-)
BALB/cJ	MGP_BALBcJ_G0025255	protein coding gene	Chr19:56634331-56735427 (-)
C3H/HeJ	MGP_C3HHeJ_G0025015	protein coding gene	Chr19:58584895-58686548 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025698	protein coding gene	Chr19:60912822-61015045 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023110	protein coding gene	Chr19:55444426-55546577 (-)
CAST/EiJ	MGP_CASTEiJ_G0024480	protein coding gene	Chr19:58664944-58768064 (-)
CBA/J	MGP_CBAJ_G0024995	protein coding gene	Chr19:63886611-63990642 (-)
DBA/2J	MGP_DBA2J_G0025127	protein coding gene	Chr19:56310965-56411734 (-)
FVB/NJ	MGP_FVBNJ_G0025088	protein coding gene	Chr19:56050879-56151670 (-)
LP/J	MGP_LPJ_G0025213	protein coding gene	Chr19:59353497-59457836 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025121	protein coding gene	Chr19:63118146-63220761 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025756	protein coding gene	Chr19:58562375-58665139 (-)
PWK/PhJ	MGP_PWKPhJ_G0024228	protein coding gene	Chr19:56314697-56416337 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024031	protein coding gene	Chr19:57228278-57332260 (-)
WSB/EiJ	MGP_WSBEiJ_G0024550	protein coding gene	Chr19:58679960-58782144 (-)

Human Ortholog

SHTN1, shootin 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SHTN1, shootin 1
Synonyms

KIAA1598, shootin-1
Links

HGNC:29319

NCBI Gene ID: 57698

neXtProt AC: NX_A0MZ66

UniProt: A0MZ66
Chr Location

10q25.3; chr10:116881477-117126586 (-) GRCh38

MGI Vertebrate Homology

Shtn1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SHTN1
Gene Tree

Shtn1

less

Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal projection of the forebrain commissural axons and partial postnatal lethality.

less

All GO Annotations

52
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

937
Tissues

39
cDNA Data

7
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase shtn1

ZFIN shtn1

less

All Sequences

40
RefSeq

5
UniProt

1
CCDS

CCDS50480.1, CCDS50481.1

Ensembl

ENSMUSG00000041362 (Evidence)
NCBI Gene

71653

			Length	Strain/Species	Flank
genomic	ENSMUSG00000041362	Ensembl Gene Model \| MGI Sequence Detail	102745	C57BL/6J	± kb
transcript	ENSMUST00000047511	Ensembl \| MGI Sequence Detail	3974	Not Applicable
polypeptide	ENSMUSP00000041378	Ensembl \| MGI Sequence Detail	631	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000039120 shootin-1

(term hierarchy)
InterPro Domains

IPR024849 Shootin-1

less

All nucleic 9

cDNA 8

Other 1

Microarray probesets 3

Summaries

All 43

Developmental Gene Expression 10

Gene Ontology 7

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:350578 Zhang K, et al., Shootin1 Regulates Retinal Ganglion Cell Neurite Development: Insights From an RGC Direct Somatic Cell Reprogramming Model. Invest Ophthalmol Vis Sci. 2024 Jun 3;65(6):41

TSS for Shtn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160004	Chr19:59064716-59064752 (-)	-202 bp
Tssr160003	Chr19:59064696-59064713 (-)	-173 bp
Tssr160002	Chr19:59064042-59064076 (-)	473 bp
Tssr160001	Chr19:59064015-59064024 (-)	512 bp
Tssr160000	Chr19:59063962-59063969 (-)	566 bp
Tssr159999	Chr19:59063933-59063954 (-)	588 bp
Tssr159998	Chr19:59030385-59030402 (-)	34,138 bp
Tssr159997	Chr19:59030350-59030367 (-)	34,173 bp
Tssr159996	Chr19:59020050-59020091 (-)	44,461 bp
Tssr159995	Chr19:58980143-58980169 (-)	84,376 bp
Tssr159994	Chr19:58976491-58976500 (-)	88,036 bp
Tssr159993	Chr19:58976416-58976431 (-)	88,108 bp
Tssr159992	Chr19:58971367-58971381 (-)	93,158 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24