Atraid MGI Mouse Gene Detail - MGI:1918918 - all-trans retinoic acid induced differentiation factor

Symbol

Atraid
Name

all-trans retinoic acid induced differentiation factor
Synonyms

0610007C21Rik, HSPC013, p18

Feature Type

protein coding gene
IDs

MGI:1918918
NCBI Gene: 381629
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr5:31205984-31211977 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 16.94 cM
Mapping Data

2 experiments

SNPs within 2kb

218 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918918	protein coding gene	Chr5:31205656-31211977 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029406	protein coding gene	Chr5:29016058-29024058 (+)
A/J	MGP_AJ_G0029372	protein coding gene	Chr5:28073584-28079912 (+)
AKR/J	MGP_AKRJ_G0029323	protein coding gene	Chr5:29223016-29231197 (+)
BALB/cJ	MGP_BALBcJ_G0029383	protein coding gene	Chr5:28590983-28597315 (+)
C3H/HeJ	MGP_C3HHeJ_G0029104	protein coding gene	Chr5:29236906-29244109 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029836	protein coding gene	Chr5:30806071-30817061 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027074	protein coding gene	Chr5:25543499-25549813 (+)
CAST/EiJ	MGP_CASTEiJ_G0028514	protein coding gene	Chr5:28323029-28329227 (+)
CBA/J	MGP_CBAJ_G0029072	protein coding gene	Chr5:31378813-31391800 (+)
DBA/2J	MGP_DBA2J_G0029221	protein coding gene	Chr5:28251611-28258013 (+)
FVB/NJ	MGP_FVBNJ_G0029179	protein coding gene	Chr5:27667958-27675749 (+)
LP/J	MGP_LPJ_G0029306	protein coding gene	Chr5:29478895-29485090 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029208	protein coding gene	Chr5:32262088-32270093 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029870	protein coding gene	Chr5:28729156-28738430 (+)
PWK/PhJ	MGP_PWKPhJ_G0028239	protein coding gene	Chr5:27373851-27380161 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028069	protein coding gene	Chr5:28104458-28111343 (+)
WSB/EiJ	MGP_WSBEiJ_G0028595	protein coding gene	Chr5:28797346-28803644 (+)

Human Ortholog

ATRAID, all-trans retinoic acid induced differentiation factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATRAID, all-trans retinoic acid induced differentiation factor
Synonyms

APR--3, APR-3, APR3, C2orf28, HSPC013, p18, PRO240
Links

HGNC:24090

NCBI Gene ID: 51374

neXtProt AC: NX_Q6UW56

UniProt: Q6UW56
Chr Location

2p23.3; chr2:27212041-27217183 (+) GRCh38

MGI Vertebrate Homology

Atraid stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ATRAID
Gene Tree

Atraid

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

2
Gene trapped

8
Radiation induced

2
Spontaneous

1
Targeted

2
Genomic Mutations

5 involving Atraid
Incidental Mutations

APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice heterozygous or homozygous for a gene trap mutation exhibit cataracts.

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All GO Annotations

25
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

73
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase atraid

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All Sequences

56
RefSeq

4
UniProt

6
CCDS

CCDS19170.1, CCDS39052.1

Ensembl

ENSMUSG00000013622 (Evidence)
NCBI Gene

381629

			Length	Strain/Species	Flank
genomic	381629	NCBI Gene Model \| MGI Sequence Detail	5994	C57BL/6J	± kb
transcript	NM_027855	RefSeq \| MGI Sequence Detail	971	C57BL/6
polypeptide	Q6PGD0	UniProt \| EBI \| MGI Sequence Detail	223	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004173 apoptosis-related protein 3

(term hierarchy)
InterPro Domains

IPR042350 All-trans retinoic acid-induced differentiation factor

IPR000742 EGF-like domain
GlyGen

Q6PGD0 3 sites, 3 N-linked glycans (3 sites)

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All nucleic 73

cDNA 73

Microarray probesets 3

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MGI:2140831

Summaries

All 60

Developmental Gene Expression 1

Diseases 1

Gene Ontology 7

Phenotypes 29
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Atraid:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45658	Chr5:31205971-31206017 (+)	10 bp
Tssr45659	Chr5:31206373-31206378 (+)	392 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24