Esm1 MGI Mouse Gene Detail - MGI:1918940 - endothelial cell-specific molecule 1

Symbol

Esm1
Name

endothelial cell-specific molecule 1
Synonyms

0610042H23Rik

Feature Type

protein coding gene
IDs

MGI:1918940
NCBI Gene: 71690
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:113346193-113354632 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 63.93 cM
Mapping Data

2 experiments

SNPs within 2kb

371 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918940	protein coding gene	Chr13:113346193-113354638 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020950	protein coding gene	Chr13:115833722-115842135 (+)
A/J	MGP_AJ_G0020900	protein coding gene	Chr13:111208081-111216674 (+)
AKR/J	MGP_AKRJ_G0020875	protein coding gene	Chr13:114552124-114560537 (+)
BALB/cJ	MGP_BALBcJ_G0020900	protein coding gene	Chr13:111891369-111899782 (+)
C3H/HeJ	MGP_C3HHeJ_G0020689	protein coding gene	Chr13:114341180-114349593 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021336	protein coding gene	Chr13:119262201-119271291 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018905	protein coding gene	Chr13:106495279-106504206 (+)
CAST/EiJ	MGP_CASTEiJ_G0020208	protein coding gene	Chr13:113990521-113998934 (+)
CBA/J	MGP_CBAJ_G0020651	protein coding gene	Chr13:123841171-123849584 (+)
DBA/2J	MGP_DBA2J_G0020774	protein coding gene	Chr13:110912138-110920551 (+)
FVB/NJ	MGP_FVBNJ_G0020758	protein coding gene	Chr13:109604062-109612607 (+)
LP/J	MGP_LPJ_G0020850	protein coding gene	Chr13:115878009-115886422 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020786	protein coding gene	Chr13:124129992-124139159 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021372	protein coding gene	Chr13:114032520-114041062 (+)
PWK/PhJ	MGP_PWKPhJ_G0019962	protein coding gene	Chr13:109673608-109682262 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019783	protein coding gene	Chr13:110337102-110345430 (+)
WSB/EiJ	MGP_WSBEiJ_G0020266	protein coding gene	Chr13:114614563-114622982 (+)

Human Ortholog

ESM1, endothelial cell specific molecule 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ESM1, endothelial cell specific molecule 1
Synonyms

endocan
Links

HGNC:3466

NCBI Gene ID: 11082

neXtProt AC: NX_Q9NQ30

UniProt: Q9NQ30
Chr Location

5q11.2; chr5:54977867-55022671 (-) GRCh38

MGI Vertebrate Homology

Esm1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ESM1
Gene Tree

Esm1

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

4
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice show delayed vascular outgrowth and reduced filopodia extension in the retina, reduced leukocyte transmigration, reduced VEGF-induced vascular permeability, and reduced cerebral edema due to ischemic stroke-induced vascular permeability.

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All GO Annotations

15
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

808
Tissues

36
cDNA Data

11
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase esm1

ZFIN esm1

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All Sequences

35
RefSeq

2
UniProt

3
CCDS

CCDS26784.1

Ensembl

ENSMUSG00000042379 (Evidence)
NCBI Gene

71690

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042379	Ensembl Gene Model \| MGI Sequence Detail	8440	C57BL/6J	± kb
transcript	ENSMUST00000038144	Ensembl \| MGI Sequence Detail	2097	Not Applicable
polypeptide	ENSMUSP00000040187	Ensembl \| MGI Sequence Detail	184	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007200 endothelial cell-specific molecule 1

(term hierarchy)
InterPro Domains

IPR038850 Endothelial cell-specific molecule 1

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR000867 Insulin-like growth factor-binding protein, IGFBP
GlyGen

Q9QYY7 1 site

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All nucleic 15

cDNA 11

Primer pair 3

Other 1

Microarray probesets 3

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MGI:2145384

Summaries

All 44

Developmental Gene Expression 11

Gene Ontology 4

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:352158 Hureau M, et al., Evaluation of Endocan as a Treatment for Acute Inflammatory Respiratory Failure. Cells. 2023 Jan 7;12(2)

TSS for Esm1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121179	Chr13:113346020-113346033 (+)	-166 bp
Tssr121180	Chr13:113346291-113346306 (+)	106 bp
Tssr121181	Chr13:113346478-113346493 (+)	293 bp
Tssr121182	Chr13:113346500-113346514 (+)	314 bp
Tssr121183	Chr13:113347855-113347859 (+)	1,664 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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