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Arhgef3 Gene Detail
Summary
  • Symbol
    Arhgef3
  • Name
    Rho guanine nucleotide exchange factor 3
  • Synonyms
    1200004I24Rik, 9830169H03Rik, C76747
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918954
    NCBI Gene: 71704
  • Alliance
    genome feature page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:26836856-27125868 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 16.09 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8320 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918954
 protein coding gene Chr14:26836418-27125873 (+)
129S1/SvImJ ENSMUSG00200014164
 protein coding gene Chr14:18647536-18936436 (+)
A/J ENSMUSG00195021607
 protein coding gene Chr14:19715656-20003614 (+)
AKR/J ENSMUSG00220023132
 protein coding gene Chr14:18819645-19107623 (+)
BALB/cJ ENSMUSG00180037101
 protein coding gene Chr14:18807507-19095454 (+)
C3H/HeJ ENSMUSG00175022594
 protein coding gene Chr14:18875031-19162973 (+)
C57BL/6NJ ENSMUSG00215030520
 protein coding gene Chr14:19118344-19407401 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019038
 protein coding gene Chr14:19573494-19741805 (+)
CAST/EiJ ENSTCUG00005026279
 protein coding gene Chr14:18979111-19266411 (+)
CBA/J ENSMUSG00210026096
 protein coding gene Chr14:19109844-19397806 (+)
DBA/2J ENSMUSG00185038734
 protein coding gene Chr14:23400608-23689760 (+)
FVB/NJ ENSMUSG00205032641
 protein coding gene Chr14:18937717-19225677 (+)
JF1/MsJ ENSUMUG00000040530
 protein coding gene Chr14:30655325-30948196 (+)
LP/J ENSMUSG00230036161
 protein coding gene Chr14:30676480-30965355 (+)
NOD/ShiLtJ ENSMUSG00190023909
 protein coding gene Chr14:19127303-19415243 (+)
NZO/HlLtJ ENSMUSG00225036398
 protein coding gene Chr14:25003369-25292433 (+)
PWK/PhJ ENSLUMG00010020941
 protein coding gene Chr14:7253769-7548049 (+)
SPRET/EiJ ENSMSPG00010042052
 protein coding gene Chr14:20795143-21056221 (+)
WSB/EiJ ENSIUOG00005029618
 protein coding gene Chr14:18957428-19245778 (+)



Homology
more
  • Human Ortholog
    ARHGEF3, Rho guanine nucleotide exchange factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGEF3, Rho guanine nucleotide exchange factor 3
  • Synonyms
    GEF3, STA3, XPLN
  • Links
    NCBI Gene ID: 50650
    UniProt: Q9NR81

  • Chr Location
    3p14.3; chr3:56727418-57079329 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit increased mean platelet volume and a mild delay in platelet recovery in response to thrombocytopenia. Mice homozygous for another null allele display enhanced muscle regeneration and resistance to age-related decline in muscle function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    637
  • Tissues
    15
  • cDNA Data
    83
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021895 Ensembl Gene Model | MGI Sequence Detail 289013 C57BL/6J ±  kb
    transcript ENSMUST00000225949 Ensembl | MGI Sequence Detail 3198 Not Applicable  
    polypeptide ENSMUSP00000153396 Ensembl | MGI Sequence Detail 551 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004256 Rho guanine nucleotide exchange factor 3
      (term hierarchy)
    • PDB
      2Z0Q
    • InterPro Domains
      IPR035899 Dbl homology (DH) domain superfamily
      IPR000219 Dbl homology domain
      IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR044129 Rho guanine nucleotide exchange factor 3, PH domain
      IPR051480 Rho guanine nucleotide exchange factor, ITSN/ARHGEF3/8 family
      IPR055251 SOS1/NGEF-like, PH domain
    Molecular
    Reagents
    less
    • All nucleic 84
      cDNA 83
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1353572, MGI:2442908
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 13
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:377560 Kalyanakrishnan K, et al., The Rho GTPase regulator ARHGEF3 orchestrates hair placode budding by coordinating cell fate and P-cadherin patterning in mice. PLoS Biol. 2026 Jan;24(1):e3003572
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory