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Mus81 Gene Detail
Summary
  • Symbol
    Mus81
  • Name
    MUS81 structure-specific endonuclease subunit
  • Synonyms
    1200008A18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918961
    NCBI Gene: 71711
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5532589-5538461 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.34 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918961
 protein coding gene Chr19:5532373-5538461 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024711
 protein coding gene Chr19:2451513-2457570 (-)
A/J MGP_AJ_G0024677
 protein coding gene Chr19:2317046-2323103 (-)
AKR/J MGP_AKRJ_G0024650
 protein coding gene Chr19:2374840-2380897 (-)
BALB/cJ MGP_BALBcJ_G0024677
 protein coding gene Chr19:2310710-2316767 (-)
C3H/HeJ MGP_C3HHeJ_G0024445
 protein coding gene Chr19:2385114-2391171 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025124
 protein coding gene Chr19:2509685-2515742 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022554
 protein coding gene Chr19:2220210-2226341 (-)
CAST/EiJ MGP_CASTEiJ_G0023917
 protein coding gene Chr19:2416529-2422515 (-)
CBA/J MGP_CBAJ_G0024417
 protein coding gene Chr19:2620958-2627015 (-)
DBA/2J MGP_DBA2J_G0024544
 protein coding gene Chr19:2296895-2302952 (-)
FVB/NJ MGP_FVBNJ_G0024511
 protein coding gene Chr19:2303106-2309497 (-)
LP/J MGP_LPJ_G0024630
 protein coding gene Chr19:2431028-2439069 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024541
 protein coding gene Chr19:2471163-2478796 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025172
 protein coding gene Chr19:2399624-2405681 (-)
PWK/PhJ MGP_PWKPhJ_G0023663
 protein coding gene Chr19:2333734-2339798 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023468
 protein coding gene Chr19:2378476-2384539 (-)
WSB/EiJ MGP_WSBEiJ_G0023979
 protein coding gene Chr19:2406472-2413268 (-)



Homology
more
  • Human Ortholog
    MUS81, MUS81 structure-specific endonuclease subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MUS81, MUS81 structure-specific endonuclease subunit
  • Synonyms
    SLX3
  • Links
    NCBI Gene ID: 80198
    neXtProt AC: NX_Q96NY9
    UniProt: Q96NY9

  • Chr Location
    11q13.1; chr11:65857126-65867653 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Mus81 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    46 phenotypes from 3 alleles in 6 genetic backgrounds
    4 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous and heterozygous null mice for one allele display increased tumor incidence and reduced life spans. Homozygous null mice for a second allele display normal life span and tumor incidence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    41
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71711 NCBI Gene Model | MGI Sequence Detail 5873 C57BL/6J ±  kb
    transcript NR_153768 RefSeq | MGI Sequence Detail 2345 C57BL/6  
    polypeptide Q91ZJ0 UniProt | EBI | MGI Sequence Detail 551 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 42

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2147484, MGI:2147686
    References
    more
    • Summaries
      All 64
      Diseases 2
      Gene Ontology 11
      Phenotypes 30
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:330401 Fernandez KC, et al., The structure-selective endonucleases GEN1 and MUS81 mediate complementary functions in safeguarding the genome of proliferating B lymphocytes. Elife. 2022 Oct 3;11:e77073
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory