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Cic Gene Detail
Summary
  • Symbol
    Cic
  • Name
    capicua transcriptional repressor
  • Synonyms
    1200010B10Rik, mKIAA0306
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918972
    NCBI Gene: 71722
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:24967129-24993584 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 13.73 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    363 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918972
 protein coding gene Chr7:24967054-24993584 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031859
 protein coding gene Chr7:23722611-23749056 (+)
A/J MGP_AJ_G0031838
 protein coding gene Chr7:23113978-23140419 (+)
AKR/J MGP_AKRJ_G0031767
 protein coding gene Chr7:23655528-23681859 (+)
BALB/cJ MGP_BALBcJ_G0031845
 protein coding gene Chr7:23322750-23352906 (+)
C3H/HeJ MGP_C3HHeJ_G0031564
 protein coding gene Chr7:24088011-24117298 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032307
 protein coding gene Chr7:24517811-24544673 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029362
 protein coding gene Chr7:24535706-24562170 (+)
CAST/EiJ MGP_CASTEiJ_G0030904
 protein coding gene Chr7:17553272-17582997 (+)
CBA/J MGP_CBAJ_G0031529
 protein coding gene Chr7:25422450-25457594 (+)
DBA/2J MGP_DBA2J_G0031683
 protein coding gene Chr7:23013847-23041746 (+)
FVB/NJ MGP_FVBNJ_G0031636
 protein coding gene Chr7:23015440-23043542 (+)
LP/J MGP_LPJ_G0031762
 protein coding gene Chr7:24027149-24055313 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031673
 protein coding gene Chr7:25132147-25164474 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032339
 protein coding gene Chr7:23361511-23389324 (+)
PWK/PhJ MGP_PWKPhJ_G0030628
 protein coding gene Chr7:17954121-17980657 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030459
 protein coding gene Chr7:14674699-14701171 (+)
WSB/EiJ MGP_WSBEiJ_G0031007
 protein coding gene Chr7:23536618-23566702 (+)



Homology
more
  • Human Ortholog
    CIC, capicua transcriptional repressor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CIC, capicua transcriptional repressor
  • Synonyms
    MRD45
  • Links
    NCBI Gene ID: 23152
    neXtProt AC: NX_Q96RK0
    UniProt: Q96RK0

  • Chr Location
    19q13.2; chr19:42268530-42295797 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cic mouse models; 1 with human CIC associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 4 alleles in 7 genetic backgrounds
    5 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit partial postnatal lethality, decreased body size, and severe lung alveolarization defects. Conditional knockout in embryonic neurons causes reduced brain size, severe growth retardation and preweaning lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    786
  • Tissues
    74
  • cDNA Data
    139
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005442 Ensembl Gene Model | MGI Sequence Detail 26456 C57BL/6J ±  kb
    transcript ENSMUST00000169266 Ensembl | MGI Sequence Detail 8221 Not Applicable  
    polypeptide ENSMUSP00000132351 Ensembl | MGI Sequence Detail 2510 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000005491 protein capicua
      (term hierarchy)
    • InterPro Domains
      IPR052412 Cell Cycle and Developmental Transcription Regulators
      IPR032147 Domain of unknown function DUF4819
      IPR009071 High mobility group box domain
      IPR036910 High mobility group box domain superfamily
    • GlyGen
      Q924A2 10 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (9 sites)
    Molecular
    Reagents
    less
    • All nucleic 143
      Genomic 2
      cDNA 140
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 8
      Phenotypes 25
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:347765 Hendrickson PG, et al., Spontaneous expression of the CIC::DUX4 fusion oncoprotein from a conditional allele potently drives sarcoma formation in genetically engineered mice. Oncogene. 2024 Apr;43(16):1223-1230
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory