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Smug1 Gene Detail
Summary
  • Symbol
    Smug1
  • Name
    single-strand selective monofunctional uracil DNA glycosylase
  • Synonyms
    1200013B09Rik, A930006H09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918976
    NCBI Gene: 71726
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:103061717-103075519 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 58.20 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    354 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918976
 protein coding gene Chr15:103061717-103077360 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022433
 protein coding gene Chr15:105395141-105399836 (-)
A/J MGP_AJ_G0022395
 protein coding gene Chr15:101234044-101238741 (-)
AKR/J MGP_AKRJ_G0022370
 protein coding gene Chr15:104306596-104311293 (-)
BALB/cJ MGP_BALBcJ_G0022399
 protein coding gene Chr15:101280751-101285446 (-)
C3H/HeJ MGP_C3HHeJ_G0022166
 protein coding gene Chr15:104392468-104397165 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022848
 protein coding gene Chr15:109289391-109294086 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020371
 protein coding gene Chr15:97001224-97005885 (-)
CAST/EiJ MGP_CASTEiJ_G0021692
 protein coding gene Chr15:105264933-105269651 (-)
CBA/J MGP_CBAJ_G0022135
 protein coding gene Chr15:113133122-113137819 (-)
DBA/2J MGP_DBA2J_G0022266
 protein coding gene Chr15:100504991-100509686 (-)
FVB/NJ MGP_FVBNJ_G0022242
 protein coding gene Chr15:99571835-99576530 (-)
LP/J MGP_LPJ_G0022335
 protein coding gene Chr15:105537997-105542692 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022264
 protein coding gene Chr15:116644758-116649453 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022860
 protein coding gene Chr15:104349729-104354424 (-)
PWK/PhJ MGP_PWKPhJ_G0021432
 protein coding gene Chr15:100686309-100691043 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021264
 protein coding gene Chr15:104184421-104189136 (-)
WSB/EiJ MGP_WSBEiJ_G0021742
 protein coding gene Chr15:104964474-104969177 (-)



Homology
more
  • Human Ortholog
    SMUG1, single-strand-selective monofunctional uracil-DNA glycosylase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMUG1, single-strand-selective monofunctional uracil-DNA glycosylase 1
  • Synonyms
    FDG, HMUDG, UNG3
  • Links
    NCBI Gene ID: 23583
    neXtProt AC: NX_Q53HV7
    UniProt: Q53HV7

  • Chr Location
    12q13.13; chr12:54121277-54189008 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired base-excision repair and decreased cellular sensitivity to 5-hydroxymethyluridine toxicity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    32
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    834
  • Tissues
    101
  • cDNA Data
    44
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036061 Ensembl Gene Model | MGI Sequence Detail 13803 C57BL/6J ±  kb
transcript ENSMUST00000229377 Ensembl | MGI Sequence Detail 3601 Not Applicable  
polypeptide ENSMUSP00000155700 Ensembl | MGI Sequence Detail 279 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015305 single-strand selective monofunctional uracil DNA glycosylase
    (term hierarchy)
  • EC
    3.2.2.-
  • InterPro Domains
    IPR039134 Single-strand selective monofunctional uracil DNA glycosylase
    IPR005122 Uracil-DNA glycosylase-like
    IPR036895 Uracil-DNA glycosylase-like domain superfamily
Molecular
Reagents
less
  • All nucleic 48
    cDNA 46
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1925034, MGI:2146306
References
more
  • Summaries
    All 44
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:288368 Kroustallaki P, et al., SMUG1 Promotes Telomere Maintenance through Telomerase RNA Processing. Cell Rep. 2019 Aug 13;28(7):1690-1702.e10
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory