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Cul2 Gene Detail
Summary
  • Symbol
    Cul2
  • Name
    cullin 2
  • Synonyms
    1300003D18Rik, 4932411N15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918995
    NCBI Gene: 71745
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:3382988-3436377 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 2.21 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    931 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918995
 protein coding gene Chr18:3382970-3436700 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024119
 protein coding gene Chr18:171043-225033 (+)
A/J MGP_AJ_G0024081
 protein coding gene Chr18:223670-278126 (+)
AKR/J MGP_AKRJ_G0024049
 protein coding gene Chr18:227637-284683 (+)
BALB/cJ MGP_BALBcJ_G0024081
 protein coding gene Chr18:254602-310068 (+)
C3H/HeJ MGP_C3HHeJ_G0023846
 protein coding gene Chr18:186518-251693 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024526
 protein coding gene Chr18:268681-324685 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021965
 protein coding gene Chr18:171065-223423 (+)
CAST/EiJ MGP_CASTEiJ_G0023325
 protein coding gene Chr18:202968-256853 (+)
CBA/J MGP_CBAJ_G0023820
 protein coding gene Chr18:211385-276507 (+)
DBA/2J MGP_DBA2J_G0023948
 protein coding gene Chr18:177994-233474 (+)
FVB/NJ MGP_FVBNJ_G0023914
 protein coding gene Chr18:187120-243608 (+)
LP/J MGP_LPJ_G0024032
 protein coding gene Chr18:220353-284403 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023942
 protein coding gene Chr18:232026-290634 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024571
 protein coding gene Chr18:183926-238744 (+)
PWK/PhJ MGP_PWKPhJ_G0023070
 protein coding gene Chr18:227733-282627 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022881
 protein coding gene Chr18:459035-515064 (+)
WSB/EiJ MGP_WSBEiJ_G0023391
 protein coding gene Chr18:206551-259266 (+)



Homology
more
  • Human Ortholog
    CUL2, cullin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CUL2, cullin 2
  • Links
    NCBI Gene ID: 8453
    neXtProt AC: NX_Q13617
    UniProt: Q13617

  • Chr Location
    10p11.21; chr10:35008504-35127006 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    7
  • cDNA Data
    10
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024231 Ensembl Gene Model | MGI Sequence Detail 53390 C57BL/6J ±  kb
transcript ENSMUST00000162301 Ensembl | MGI Sequence Detail 3828 Not Applicable  
polypeptide ENSMUSP00000125403 Ensembl | MGI Sequence Detail 745 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1922970, MGI:2147215
References
more
  • Summaries
    All 51
    Developmental Gene Expression 7
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:358022 Littlejohn R, et al., Inhibition of cardiomyocyte neddylation impairs embryonic cardiac morphogenesis. J Mol Cell Cardiol. 2024 Oct 20;197:40-44
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory