Marchf8 MGI Mouse Gene Detail - MGI:1919029 - membrane associated ring-CH-type finger 8

Symbol

Marchf8
Name

membrane associated ring-CH-type finger 8
Synonyms

1300017E09Rik, March8, Mir

Feature Type

protein coding gene
IDs

MGI:1919029
NCBI Gene: 71779
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr6:116314985-116386501 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 53.78 cM, cytoband F1
Mapping Data

3 experiments

SNPs within 2kb

1876 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919029	protein coding gene	Chr6:116312546-116386501 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031166	protein coding gene	Chr6:119002704-119083008 (+)
A/J	MGP_AJ_G0031136	protein coding gene	Chr6:114439811-114510633 (+)
AKR/J	MGP_AKRJ_G0031066	protein coding gene	Chr6:117494812-117568431 (+)
BALB/cJ	MGP_BALBcJ_G0031146	protein coding gene	Chr6:114244761-114320898 (+)
C3H/HeJ	MGP_C3HHeJ_G0030562	protein coding gene	Chr6:66720672-66793303 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031605	protein coding gene	Chr6:122064092-122151798 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028769	protein coding gene	Chr6:111441219-111510292 (+)
CAST/EiJ	MGP_CASTEiJ_G0030253	protein coding gene	Chr6:117892755-117966290 (+)
CBA/J	MGP_CBAJ_G0030832	protein coding gene	Chr6:126838832-126924297 (+)
DBA/2J	MGP_DBA2J_G0030986	protein coding gene	Chr6:113353443-113425140 (+)
FVB/NJ	MGP_FVBNJ_G0030939	protein coding gene	Chr6:112544774-112620840 (+)
LP/J	MGP_LPJ_G0031065	protein coding gene	Chr6:119012008-119090840 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030974	protein coding gene	Chr6:130982457-131068221 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031633	protein coding gene	Chr6:117540019-117613324 (+)
PWK/PhJ	MGP_PWKPhJ_G0029969	protein coding gene	Chr6:112372946-112443515 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029797	protein coding gene	Chr6:116280257-116356437 (+)
WSB/EiJ	MGP_WSBEiJ_G0030337	protein coding gene	Chr6:117808298-117884916 (+)

Human Ortholog

MARCHF8, membrane associated ring-CH-type finger 8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MARCHF8, membrane associated ring-CH-type finger 8
Synonyms

c-MIR, CMIR, MARCH8, MARCH-VIII, MIR, RNF178
Links

HGNC:23356

NCBI Gene ID: 220972

neXtProt AC: NX_Q5T0T0

UniProt: Q5T0T0
Chr Location

10q11.21-q11.22; chr10:45454585-45594907 (-) GRCh38

MGI Vertebrate Homology

Marchf8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MARCHF8
Gene Tree

Marchf8

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Endonuclease-mediated

6
Gene trapped

24
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit a normal CD4+ T cell compartment in the thymus.

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All GO Annotations

29
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

148
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase marchf8

ZFIN marchf8

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All Sequences

105
RefSeq

28
UniProt

10
CCDS

CCDS20451.1, CCDS85138.1

Ensembl

ENSMUSG00000025702 (Evidence)
NCBI Gene

71779

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025702	Ensembl Gene Model \| MGI Sequence Detail	71517	C57BL/6J	± kb
transcript	ENSMUST00000123405	Ensembl \| MGI Sequence Detail	2102	Not Applicable
polypeptide	ENSMUSP00000144936	Ensembl \| MGI Sequence Detail	568	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000010182 E3 ubiquitin-protein ligase MARCHF8

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR011016 Zinc finger, RING-CH-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

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All nucleic 148

cDNA 148

Microarray probesets 3

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MGI:6368856

Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Marchf8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58363	Chr6:116314832-116314859 (+)	-139 bp
Tssr58364	Chr6:116314861-116314872 (+)	-118 bp
Tssr58365	Chr6:116314960-116314971 (+)	-19 bp
Tssr58366	Chr6:116314974-116315044 (+)	24 bp
Tssr58367	Chr6:116315261-116315293 (+)	292 bp
Tssr58368	Chr6:116315334-116315353 (+)	359 bp
Tssr58369	Chr6:116327863-116327898 (+)	12,896 bp
Tssr58370	Chr6:116331830-116331831 (+)	16,846 bp
Tssr58371	Chr6:116335917-116335934 (+)	20,941 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24