Gtf2a1l MGI Mouse Gene Detail - MGI:1919078 - general transcription factor IIA, 1-like

Symbol

Gtf2a1l
Name

general transcription factor IIA, 1-like
Synonyms

1700011N16Rik, Alf, Gtf2a1lf

Feature Type

protein coding gene
IDs

MGI:1919078
NCBI Gene: 71828
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr17:88976088-89022580 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 58.22 cM, cytoband E5
Mapping Data

2 experiments

SNPs within 2kb

1518 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919078	protein coding gene	Chr17:88972921-89022585 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024112	protein coding gene	Chr17:92162089-92207063 (+)
A/J	MGP_AJ_G0024072	protein coding gene	Chr17:89192320-89239332 (+)
AKR/J	MGP_AKRJ_G0024041	protein coding gene	Chr17:90682684-90733217 (+)
BALB/cJ	MGP_BALBcJ_G0024073	protein coding gene	Chr17:89016760-89062929 (+)
C3H/HeJ	MGP_C3HHeJ_G0023838	protein coding gene	Chr17:91574927-91626812 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024518	protein coding gene	Chr17:95379506-95431089 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021956	protein coding gene	Chr17:84252065-84297640 (+)
CAST/EiJ	MGP_CASTEiJ_G0023317	protein coding gene	Chr17:92448632-92498715 (+)
CBA/J	MGP_CBAJ_G0023811	protein coding gene	Chr17:99398124-99457706 (+)
DBA/2J	MGP_DBA2J_G0023940	protein coding gene	Chr17:87576485-87622049 (+)
FVB/NJ	MGP_FVBNJ_G0023906	protein coding gene	Chr17:87112906-87159464 (+)
LP/J	MGP_LPJ_G0024024	protein coding gene	Chr17:92961889-93013431 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023934	protein coding gene	Chr17:99177232-99233456 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024563	protein coding gene	Chr17:91238610-91289982 (+)
PWK/PhJ	MGP_PWKPhJ_G0023062	protein coding gene	Chr17:87271377-87320487 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022873	protein coding gene	Chr17:87970359-88018794 (+)
WSB/EiJ	MGP_WSBEiJ_G0023383	protein coding gene	Chr17:92091476-92144075 (+)

Human Ortholog

GTF2A1L, general transcription factor IIA subunit 1 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GTF2A1L, general transcription factor IIA subunit 1 like
Synonyms

ALF
Links

HGNC:30727

NCBI Gene ID: 11036

neXtProt AC: NX_Q9UNN4

UniProt: Q9UNN4
Chr Location

2p16.3; chr2:48617798-48733148 (+) GRCh38

MGI Vertebrate Homology

Gtf2a1l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GTF2A1L
Gene Tree

Gtf2a1l

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

900
Tissues

164
cDNA Data

9
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gtf2a1l

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All Sequences

37
RefSeq

4
UniProt

2
CCDS

CCDS29024.1

Ensembl

ENSMUSG00000024154 (Evidence)
NCBI Gene

71828

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024154	Ensembl Gene Model \| MGI Sequence Detail	46493	C57BL/6J	± kb
transcript	ENSMUST00000024970	Ensembl \| MGI Sequence Detail	1621	Not Applicable
polypeptide	ENSMUSP00000024970	Ensembl \| MGI Sequence Detail	468	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008311 TFIIA-alpha and beta-like factor

(term hierarchy)
InterPro Domains

IPR004855 Transcription factor IIA, alpha/beta subunit

IPR009088 Transcription factor IIA, beta-barrel

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All nucleic 13

cDNA 10

Primer pair 3

Microarray probesets 3

Summaries

All 37

Developmental Gene Expression 5

Gene Ontology 6

Phenotypes 3
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:302834 Yu C, et al., TBPL2/TFIIA complex establishes the maternal transcriptome through oocyte-specific promoter usage. Nat Commun. 2020 Dec 22;11(1):6439

TSS for Gtf2a1l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146249	Chr17:88976071-88976082 (+)	-11 bp
Tssr146250	Chr17:88976090-88976129 (+)	22 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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