Pdilt MGI Mouse Gene Detail - MGI:1919080 - protein disulfide isomerase-like, testis expressed

Symbol

Pdilt
Name

protein disulfide isomerase-like, testis expressed
Synonyms

1700007B13Rik, PDILT

Feature Type

protein coding gene
IDs

MGI:1919080
NCBI Gene: 71830
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr7:119085810-119122712 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 63.90 cM, cytoband F3
Mapping Data

2 experiments

SNPs within 2kb

992 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919080	protein coding gene	Chr7:119085809-119128259 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032911	protein coding gene	Chr7:123384268-123424141 (-)
A/J	MGP_AJ_G0032894	protein coding gene	Chr7:120216789-120247873 (-)
AKR/J	MGP_AKRJ_G0032826	protein coding gene	Chr7:123313376-123347820 (-)
BALB/cJ	MGP_BALBcJ_G0032899	protein coding gene	Chr7:119940481-119975978 (-)
C3H/HeJ	MGP_C3HHeJ_G0032609	protein coding gene	Chr7:123203615-123235746 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033405	protein coding gene	Chr7:128280592-128318338 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030377	protein coding gene	Chr7:121650921-121683326 (-)
CAST/EiJ	MGP_CASTEiJ_G0031937	protein coding gene	Chr7:114967126-115001631 (-)
CBA/J	MGP_CBAJ_G0032582	protein coding gene	Chr7:132571175-132604237 (-)
DBA/2J	MGP_DBA2J_G0032734	protein coding gene	Chr7:118257533-118288681 (-)
FVB/NJ	MGP_FVBNJ_G0032687	protein coding gene	Chr7:118099123-118136210 (-)
LP/J	MGP_LPJ_G0032828	protein coding gene	Chr7:124858731-124893959 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032719	protein coding gene	Chr7:134029342-134068627 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033425	protein coding gene	Chr7:122287891-122322446 (-)
PWK/PhJ	MGP_PWKPhJ_G0031645	protein coding gene	Chr7:111175322-111207137 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031491	protein coding gene	Chr7:109020966-109072315 (-)
WSB/EiJ	MGP_WSBEiJ_G0032050	protein coding gene	Chr7:123194762-123225904 (-)

Human Ortholog

PDILT, protein disulfide isomerase like, testis expressed

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PDILT, protein disulfide isomerase like, testis expressed
Synonyms

PDIA7
Links

HGNC:27338

NCBI Gene ID: 204474

neXtProt AC: NX_Q8N807

UniProt: Q8N807
Chr Location

16p12.3; chr16:20359175-20404737 (-) GRCh38

MGI Vertebrate Homology

Pdilt stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PDILT
Gene Tree

Pdilt

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
2 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit male infertility and abnormal sperm physiology.

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All GO Annotations

12
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

9
UniProt

2
CCDS

CCDS52378.1

Ensembl

ENSMUSG00000030968 (Evidence)
NCBI Gene

71830

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030968	Ensembl Gene Model \| MGI Sequence Detail	36903	C57BL/6J	± kb
transcript	ENSMUST00000033267	Ensembl \| MGI Sequence Detail	2146	Not Applicable
polypeptide	ENSMUSP00000033267	Ensembl \| MGI Sequence Detail	588	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012503 protein disulfide-isomerase-like protein of the testis

(term hierarchy)
InterPro Domains

IPR013766 Thioredoxin domain

IPR036249 Thioredoxin-like superfamily
GlyGen

Q9DAN1 5 sites, 2 N-linked glycans (3 sites)

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All nucleic 5

cDNA 5

Microarray probesets 3

Summaries

All 22

Gene Ontology 4

Phenotypes 2
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:210341 Fujihara Y, et al., GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in mice. Biol Reprod. 2014 Mar;90(3):60

TSS for Pdilt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr74487	Chr7:119122700-119122714 (-)	5 bp
Tssr74486	Chr7:119122685-119122697 (-)	21 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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