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Tex44 Gene Detail
Summary
  • Symbol
    Tex44
  • Name
    testis expressed 44
  • Synonyms
    1700019O17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919113
    NCBI Gene: 71863
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:86354051-86355771 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 43.94 cM, cytoband C5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    120 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919113
 protein coding gene Chr1:86354051-86355774 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016248
 protein coding gene Chr1:87689514-87691147 (+)
A/J MGP_AJ_G0016229
 protein coding gene Chr1:84438676-84440309 (+)
AKR/J MGP_AKRJ_G0016190
 protein coding gene Chr1:86908726-86910449 (+)
BALB/cJ MGP_BALBcJ_G0016186
 protein coding gene Chr1:84559835-84561558 (+)
C3H/HeJ MGP_C3HHeJ_G0016014
 protein coding gene Chr1:87140969-87142602 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016642
 protein coding gene Chr1:91023674-91025397 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014364
 protein coding gene Chr1:78926517-78928431 (+)
CAST/EiJ MGP_CASTEiJ_G0015599
 protein coding gene Chr1:86385977-86387610 (+)
CBA/J MGP_CBAJ_G0015990
 protein coding gene Chr1:93851447-93853170 (+)
DBA/2J MGP_DBA2J_G0016093
 protein coding gene Chr1:83745538-83747171 (+)
FVB/NJ MGP_FVBNJ_G0016092
 protein coding gene Chr1:82802710-82804343 (+)
LP/J MGP_LPJ_G0016164
 protein coding gene Chr1:88791826-88793459 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016118
 protein coding gene Chr1:97121420-97123143 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016685
 protein coding gene Chr1:87020069-87021702 (+)
PWK/PhJ MGP_PWKPhJ_G0015386
 protein coding gene Chr1:83033602-83035325 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015166
 protein coding gene Chr1:85979794-85981517 (+)
WSB/EiJ MGP_WSBEiJ_G0015663
 protein coding gene Chr1:86668741-86670374 (+)



Homology
more
  • Human Ortholog
    TEX44, testis expressed 44
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TEX44, testis expressed 44
  • Synonyms
    C2orf57
  • Links
    NCBI Gene ID: 165100
    neXtProt AC: NX_Q53QW1
    UniProt: Q53QW1

  • Chr Location
    2q37.1; chr2:231592864-231594276 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males homozygous for a knock-out allele are severely subfertile and show decreased fertilization frequency both in vivo and in vitro, asthenozoospermia, reduced sperm mitochondrial activity, and abnormal sperm morphology including disjunction and hairpin bending between the midpiece and the principal piece of the flagellum.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71863 NCBI Gene Model | MGI Sequence Detail 1721 C57BL/6J ±  kb
    transcript NM_027966 RefSeq | MGI Sequence Detail 1751 C57BL/6  
    polypeptide Q9DA60 UniProt | EBI | MGI Sequence Detail 530 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR031460 Protein of unknown function DUF4678
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 2
    References
    more
    • Summaries
      All 24
      Gene Ontology 2
      Phenotypes 6
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:354514 Dupuis S, et al., The lack of Tex44 causes severe subfertility with flagellar abnormalities in male mice. Cell Mol Biol Lett. 2024 May 15;29(1):74
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory