Aox4 MGI Mouse Gene Detail - MGI:1919122

Symbol

Aox4
Name

aldehyde oxidase 4
Synonyms

2310003G12Rik, AOH2

Feature Type

protein coding gene
IDs

MGI:1919122
NCBI Gene: 71872
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:58249556-58307756 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 28.97 cM
Mapping Data

4 experiments

SNPs within 2kb

1940 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919122	protein coding gene	Chr1:58249556-58307759 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016047	protein coding gene	Chr1:58052133-58117238 (+)
A/J	MGP_AJ_G0016030	protein coding gene	Chr1:56035060-56094188 (+)
AKR/J	MGP_AKRJ_G0015986	protein coding gene	Chr1:57541367-57602922 (+)
BALB/cJ	MGP_BALBcJ_G0015985	protein coding gene	Chr1:56064422-56124154 (+)
C3H/HeJ	MGP_C3HHeJ_G0015817	protein coding gene	Chr1:57815029-57878883 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016438	protein coding gene	Chr1:60418070-60480232 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014160	protein coding gene	Chr1:51971489-52032186 (+)
CAST/EiJ	MGP_CASTEiJ_G0015399	protein coding gene	Chr1:57065932-57124507 (+)
CBA/J	MGP_CBAJ_G0015789	protein coding gene	Chr1:62172738-62246957 (+)
DBA/2J	MGP_DBA2J_G0015890	protein coding gene	Chr1:55437168-55498191 (+)
FVB/NJ	MGP_FVBNJ_G0015892	protein coding gene	Chr1:54772328-54830910 (+)
LP/J	MGP_LPJ_G0015962	protein coding gene	Chr1:58943477-59015963 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015912	protein coding gene	Chr1:65186799-65247155 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016485	protein coding gene	Chr1:57534508-57594609 (+)
PWK/PhJ	MGP_PWKPhJ_G0015185	protein coding gene	Chr1:54825476-54884183 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014966	protein coding gene	Chr1:57112880-57170976 (+)
WSB/EiJ	MGP_WSBEiJ_G0015462	protein coding gene	Chr1:57201289-57263226 (+)

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MGI Vertebrate Homology

Aox4 stringent orthology
1 mouse;1 rat;2 zebrafish
Protein SuperFamily

Xanthine_DH
Gene Tree

Aox4

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

1
Genomic Mutations

2 involving Aox4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

79 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit a slight decrease in prenatal survival and epidermal thickening that is exacerbated by UV treatment.

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All GO Annotations

15
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

2
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

80
RefSeq

6
UniProt

3
CCDS

CCDS14970.1

Ensembl

ENSMUSG00000038242 (Evidence)
NCBI Gene

71872

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038242	Ensembl Gene Model \| MGI Sequence Detail	58201	C57BL/6J	± kb
transcript	ENSMUST00000040442	Ensembl \| MGI Sequence Detail	4973	Not Applicable
polypeptide	ENSMUSP00000048929	Ensembl \| MGI Sequence Detail	1336	Not Applicable

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UniProt

3 Sequences
EC

1.17.3.-, 1.2.3.1
InterPro Domains

IPR002888 [2Fe-2S]-binding

IPR036884 [2Fe-2S]-binding domain superfamily

IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site

IPR036010 2Fe-2S ferredoxin-like superfamily

IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain

IPR014313 Aldehyde oxidase

IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead

IPR036856 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily

IPR008274 Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain

IPR016208 Aldehyde oxidase/xanthine dehydrogenase-like

IPR037165 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily

IPR046867 Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain

IPR012675 Beta-grasp domain superfamily

IPR005107 CO dehydrogenase flavoprotein, C-terminal

IPR036683 CO dehydrogenase flavoprotein, C-terminal domain superfamily

IPR016166 FAD-binding domain, PCMH-type

IPR036318 FAD-binding, type PCMH-like superfamily

IPR016167 FAD-binding, type PCMH, subdomain 1

IPR016169 FAD-binding, type PCMH, subdomain 2

IPR002346 Molybdopterin dehydrogenase, FAD-binding

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All nucleic 13

cDNA 13

Microarray probesets 3

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 7
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:264374 Terao M, et al., Mouse aldehyde-oxidase-4 controls diurnal rhythms, fat deposition and locomotor activity. Sci Rep. 2016 Jul 26;6:30343

TSS for Aox4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6763	Chr1:58249602-58249616 (+)	53 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24