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Apmap Gene Detail
Summary
  • Symbol
    Apmap
  • Name
    adipocyte plasma membrane associated protein
  • Synonyms
    2310001A20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919131
    NCBI Gene: 71881
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:150425000-150450487 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 74.68 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    716 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919131
 protein coding gene Chr2:150425000-150450487 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026627
 protein coding gene Chr2:155031419-155056896 (-)
A/J MGP_AJ_G0026594
 protein coding gene Chr2:148788181-148813867 (-)
AKR/J MGP_AKRJ_G0026565
 protein coding gene Chr2:153108337-153135742 (-)
BALB/cJ MGP_BALBcJ_G0026604
 protein coding gene Chr2:149208145-149236505 (-)
C3H/HeJ MGP_C3HHeJ_G0026347
 protein coding gene Chr2:153549772-153575148 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027052
 protein coding gene Chr2:159564356-159590075 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024424
 protein coding gene Chr2:142657038-142683358 (-)
CAST/EiJ MGP_CASTEiJ_G0025807
 protein coding gene Chr2:153787837-153813005 (-)
CBA/J MGP_CBAJ_G0026326
 protein coding gene Chr2:165412370-165441962 (-)
DBA/2J MGP_DBA2J_G0026460
 protein coding gene Chr2:148028166-148053587 (-)
FVB/NJ MGP_FVBNJ_G0026425
 protein coding gene Chr2:146487734-146514421 (-)
LP/J MGP_LPJ_G0026564
 protein coding gene Chr2:155171354-155197471 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026447
 protein coding gene Chr2:169520075-169547091 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027107
 protein coding gene Chr2:153044110-153073729 (-)
PWK/PhJ MGP_PWKPhJ_G0025542
 protein coding gene Chr2:147662095-147687946 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025344
 protein coding gene Chr2:151966022-151991259 (-)
WSB/EiJ MGP_WSBEiJ_G0025880
 protein coding gene Chr2:154008048-154036975 (-)



Homology
more
  • Human Ortholog
    APMAP, adipocyte plasma membrane associated protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APMAP, adipocyte plasma membrane associated protein
  • Synonyms
    BSCv, C20orf3
  • Links
    NCBI Gene ID: 57136
    neXtProt AC: NX_Q9HDC9
    UniProt: Q9HDC9

  • Chr Location
    20p11.21; chr20:24962925-24992751 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show spatial memory deficits. Under a high-fat diet, homozygous deletion of exon 1 results in increased insulin sensitivity, improved glucose tolerance, increased respiratory exchange ratio, decreased inflammatory marker gene expression, and reduced adipocyte size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    1
  • cDNA Data
    85
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71881 NCBI Gene Model | MGI Sequence Detail 25488 C57BL/6J ±  kb
    transcript NM_001356492 RefSeq | MGI Sequence Detail 2427 C57BL/6  
    polypeptide Q9D7N9 UniProt | EBI | MGI Sequence Detail 415 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000004139 adipocyte plasma membrane-associated protein
      (term hierarchy)
    • InterPro Domains
      IPR011042 Six-bladed beta-propeller, TolB-like
      IPR018119 Strictosidine synthase, conserved region
    • GlyGen
      Q9D7N9 2 sites, 7 N-linked glycans (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 85
      cDNA 85

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138883
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory