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Ppm1j Gene Detail
Summary
  • Symbol
    Ppm1j
  • Name
    protein phosphatase 1J
  • Synonyms
    2310008J22Rik, PP2Czeta, Ppp2cz
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919137
    NCBI Gene: 71887
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:104688372-104693334 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 45.85 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    156 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919137
 protein coding gene Chr3:104688322-104693334 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027709
 protein coding gene Chr3:106104389-106109350 (+)
A/J MGP_AJ_G0027669
 protein coding gene Chr3:102722986-102727947 (+)
AKR/J MGP_AKRJ_G0027634
 protein coding gene Chr3:105249161-105254122 (+)
BALB/cJ MGP_BALBcJ_G0027681
 protein coding gene Chr3:102507990-102512952 (+)
C3H/HeJ MGP_C3HHeJ_G0027411
 protein coding gene Chr3:105630660-105635621 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028125
 protein coding gene Chr3:110068362-110073324 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025465
 protein coding gene Chr3:98833204-98838201 (+)
CAST/EiJ MGP_CASTEiJ_G0026867
 protein coding gene Chr3:104745843-104750810 (+)
CBA/J MGP_CBAJ_G0027386
 protein coding gene Chr3:113815340-113820301 (+)
DBA/2J MGP_DBA2J_G0027528
 protein coding gene Chr3:101976835-101981797 (+)
FVB/NJ MGP_FVBNJ_G0027496
 protein coding gene Chr3:99898212-99903173 (+)
LP/J MGP_LPJ_G0027635
 protein coding gene Chr3:107484059-107489020 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027526
 protein coding gene Chr3:119938988-119943950 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028180
 protein coding gene Chr3:104809459-104814426 (+)
PWK/PhJ MGP_PWKPhJ_G0026593
 protein coding gene Chr3:101752927-101757894 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026414
 protein coding gene Chr3:102846221-102851178 (+)
WSB/EiJ MGP_WSBEiJ_G0026947
 protein coding gene Chr3:105387725-105392687 (+)



Homology
more
  • Human Ortholog
    PPM1J, protein phosphatase, Mg2+/Mn2+ dependent 1J
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPM1J, protein phosphatase, Mg2+/Mn2+ dependent 1J
  • Synonyms
    PP2CZ, PP2C-zeta, PP2Czeta, PPP2CZ
  • Links
    NCBI Gene ID: 333926
    neXtProt AC: NX_Q5JR12
    UniProt: Q5JR12

  • Chr Location
    1p13.2; chr1:112709994-112715332 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Ppm1j
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    17 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    5
  • cDNA Data
    20
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002228 Ensembl Gene Model | MGI Sequence Detail 4963 C57BL/6J ±  kb
transcript ENSMUST00000002298 Ensembl | MGI Sequence Detail 1721 Not Applicable  
polypeptide ENSMUSP00000002298 Ensembl | MGI Sequence Detail 507 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 20

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 4
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory