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Pla2g4e Gene Detail
Summary
  • Symbol
    Pla2g4e
  • Name
    phospholipase A2, group IVE
  • Synonyms
    2310026J01Rik, Pla2epsilon
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919144
    NCBI Gene: 329502
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:119996893-120075816 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 60.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1702 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919144
 protein coding gene Chr2:119996893-120075816 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026361
 protein coding gene Chr2:123028319-123106786 (-)
A/J MGP_AJ_G0026322
 protein coding gene Chr2:117984801-118057580 (-)
AKR/J MGP_AKRJ_G0026301
 protein coding gene Chr2:121272381-121350509 (-)
BALB/cJ MGP_BALBcJ_G0026335
 protein coding gene Chr2:118225965-118299857 (-)
C3H/HeJ MGP_C3HHeJ_G0026081
 protein coding gene Chr2:121746585-121824614 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026782
 protein coding gene Chr2:127033524-127115562 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024162
 protein coding gene Chr2:113006888-113077631 (-)
CAST/EiJ MGP_CASTEiJ_G0025543
 protein coding gene Chr2:122060848-122140724 (-)
CBA/J MGP_CBAJ_G0026057
 protein coding gene Chr2:131474430-131557842 (-)
DBA/2J MGP_DBA2J_G0026196
 protein coding gene Chr2:117373476-117448362 (-)
FVB/NJ MGP_FVBNJ_G0026158
 protein coding gene Chr2:116209542-116283306 (-)
LP/J MGP_LPJ_G0026297
 protein coding gene Chr2:123281703-123359977 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026177
 protein coding gene Chr2:135784723-135866401 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026837
 protein coding gene Chr2:121401731-121480185 (-)
PWK/PhJ MGP_PWKPhJ_G0025279
 protein coding gene Chr2:116974282-117048266 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025078
 protein coding gene Chr2:120592531-120675390 (-)
WSB/EiJ MGP_WSBEiJ_G0025612
 protein coding gene Chr2:122236884-122314694 (-)



Homology
more
  • Human Ortholog
    PLA2G4E, phospholipase A2 group IVE
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLA2G4E, phospholipase A2 group IVE
  • Links
    NCBI Gene ID: 123745
    neXtProt AC: NX_Q3MJ16
    UniProt: Q3MJ16

  • Chr Location
    15q15.1; chr15:41981394-42051190 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased N-acylethanolamine-related lipids and increased susceptibility to imiquimod-induced skin inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    97
  • cDNA Data
    10
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 329502 NCBI Gene Model | MGI Sequence Detail 78924 C57BL/6J ±  kb
    transcript NM_001395470 RefSeq | MGI Sequence Detail 4599 C57BL/6  
    polypeptide Q50L42 UniProt | EBI | MGI Sequence Detail 875 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Primer pair 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory