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Tmem106b Gene Detail
Summary
  • Symbol
    Tmem106b
  • Name
    transmembrane protein 106B
  • Synonyms
    2310036D22Rik, 5830455K21Rik, 6430519M21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919150
    NCBI Gene: 71900
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:13069758-13089268 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 5.38 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    757 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919150
 protein coding gene Chr6:13069758-13089268 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030457
 protein coding gene Chr6:10141006-10160516 (+)
A/J MGP_AJ_G0030430
 protein coding gene Chr6:9756072-9775570 (+)
AKR/J MGP_AKRJ_G0030357
 protein coding gene Chr6:10090002-10109512 (+)
BALB/cJ MGP_BALBcJ_G0030439
 protein coding gene Chr6:9745977-9766077 (+)
C3H/HeJ MGP_C3HHeJ_G0030153
 protein coding gene Chr6:10008605-10028137 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030894
 protein coding gene Chr6:10573295-10595735 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028105
 protein coding gene Chr6:9001636-9020977 (+)
CAST/EiJ MGP_CASTEiJ_G0029555
 protein coding gene Chr6:9873143-9894359 (+)
CBA/J MGP_CBAJ_G0030131
 protein coding gene Chr6:10762256-10782497 (+)
DBA/2J MGP_DBA2J_G0030275
 protein coding gene Chr6:9683395-9702903 (+)
FVB/NJ MGP_FVBNJ_G0030229
 protein coding gene Chr6:9589942-9609452 (+)
LP/J MGP_LPJ_G0030362
 protein coding gene Chr6:10091333-10110822 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030265
 protein coding gene Chr6:11522820-11542849 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030924
 protein coding gene Chr6:9976703-9996213 (+)
PWK/PhJ MGP_PWKPhJ_G0029269
 protein coding gene Chr6:9433259-9453043 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029105
 protein coding gene Chr6:9907056-9926586 (+)
WSB/EiJ MGP_WSBEiJ_G0029631
 protein coding gene Chr6:9904795-9925027 (+)



Homology
more
  • Human Ortholog
    TMEM106B, transmembrane protein 106B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM106B, transmembrane protein 106B
  • Synonyms
    HLD16
  • Links
    NCBI Gene ID: 54664
    neXtProt AC: NX_Q9NUM4
    UniProt: Q9NUM4

  • Chr Location
    7p21.3; chr7:12211270-12243367 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TMEM106B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 4 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout impairs retrograde lysosomal transport, which causes vacuolization of motor neurons, leading to impaired motor coordination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    825
  • Tissues
    43
  • cDNA Data
    15
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71900 NCBI Gene Model | MGI Sequence Detail 19511 C57BL/6J ±  kb
    transcript NM_027992 RefSeq | MGI Sequence Detail 6099 C57BL/6  
    polypeptide Q80X71 UniProt | EBI | MGI Sequence Detail 275 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000029776 transmembrane protein 106B
      (term hierarchy)
    • InterPro Domains
      IPR009790 Transmembrane protein 106
      IPR048509 Transmembrane protein 106, C-terminal domain
      IPR048511 Transmembrane protein 106, N-terminal
    • GlyGen
      Q80X71 6 sites, 9 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1923336, MGI:2141406, MGI:2141463
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 34
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:347931 Edwards GA 3rd, et al., TMEM106B coding variant is protective and deletion detrimental in a mouse model of tauopathy. Acta Neuropathol. 2024 Mar 25;147(1):61
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory