Rbpms2 MGI Mouse Gene Detail - MGI:1919223 - RNA binding protein with multiple splicing 2

Symbol

Rbpms2
Name

RNA binding protein with multiple splicing 2
Synonyms

2400008B06Rik

Feature Type

protein coding gene
IDs

MGI:1919223
NCBI Gene: 71973
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr9:65536930-65567810 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 35.43 cM
Mapping Data

2 experiments

SNPs within 2kb

813 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919223	protein coding gene	Chr9:65536638-65567818 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034964	protein coding gene	Chr9:65394348-65434323 (+)
A/J	MGP_AJ_G0034944	protein coding gene	Chr9:63175451-63209404 (+)
AKR/J	MGP_AKRJ_G0034874	protein coding gene	Chr9:64676023-64708663 (+)
BALB/cJ	MGP_BALBcJ_G0034937	protein coding gene	Chr9:62894147-62925859 (+)
C3H/HeJ	MGP_C3HHeJ_G0034647	protein coding gene	Chr9:65208315-65244315 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035456	protein coding gene	Chr9:67172962-67204819 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032367	protein coding gene	Chr9:62818336-62850273 (+)
CAST/EiJ	MGP_CASTEiJ_G0033968	protein coding gene	Chr9:65382131-65414576 (+)
CBA/J	MGP_CBAJ_G0034618	protein coding gene	Chr9:69526156-69560603 (+)
DBA/2J	MGP_DBA2J_G0034777	protein coding gene	Chr9:62941042-62972949 (+)
FVB/NJ	MGP_FVBNJ_G0034719	protein coding gene	Chr9:62268934-62301589 (+)
LP/J	MGP_LPJ_G0034860	protein coding gene	Chr9:65650969-65683482 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034761	protein coding gene	Chr9:70745895-70781856 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035478	protein coding gene	Chr9:64775822-64813376 (+)
PWK/PhJ	MGP_PWKPhJ_G0033672	protein coding gene	Chr9:63145979-63178028 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033506	protein coding gene	Chr9:65069425-65103369 (+)
WSB/EiJ	MGP_WSBEiJ_G0034081	protein coding gene	Chr9:64680385-64710926 (+)

Human Ortholog

RBPMS2, RNA binding protein, mRNA processing factor 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RBPMS2, RNA binding protein, mRNA processing factor 2
Links

HGNC:19098

NCBI Gene ID: 348093

neXtProt AC: NX_Q6ZRY4

UniProt: Q6ZRY4
Chr Location

15q22.31; chr15:64739891-64775589 (-) GRCh38

MGI Vertebrate Homology

Rbpms2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RBPMS2
Gene Tree

Rbpms2

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

278
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

269
Targeted

2
Genomic Mutations

1 involving Rbpms2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

205 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

23
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

802
Tissues

75
cDNA Data

69
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RBPMS2

Xenbase rbpms2

ZFIN rbpms2a, rbpms2b

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All Sequences

52
RefSeq

10
UniProt

4
CCDS

CCDS23296.1

Ensembl

ENSMUSG00000032387 (Evidence)
NCBI Gene

71973

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032387	Ensembl Gene Model \| MGI Sequence Detail	30881	C57BL/6J	± kb
transcript	ENSMUST00000055844	Ensembl \| MGI Sequence Detail	1987	Not Applicable
polypeptide	ENSMUSP00000057600	Ensembl \| MGI Sequence Detail	206	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013827 RNA-binding protein with multiple splicing 2

(term hierarchy)
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR034787 RBPMS2, RNA recognition motif

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

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All nucleic 71

cDNA 69

Primer pair 2

Microarray probesets 3

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MGI:2143015

Summaries

All 42

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rbpms2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85716	Chr9:65536892-65536965 (+)	-1 bp
Tssr85717	Chr9:65537834-65537881 (+)	928 bp
Tssr85718	Chr9:65537886-65537899 (+)	963 bp
Tssr85719	Chr9:65537969-65537985 (+)	1,047 bp
Tssr85720	Chr9:65538011-65538018 (+)	1,085 bp
Tssr85721	Chr9:65538036-65538043 (+)	1,110 bp
Tssr85722	Chr9:65538092-65538102 (+)	1,167 bp
Tssr85723	Chr9:65538352-65538370 (+)	1,431 bp
Tssr85724	Chr9:65545121-65545134 (+)	8,198 bp
Tssr85725	Chr9:65566938-65566960 (+)	30,019 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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