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Snx10 Gene Detail
Summary
  • Symbol
    Snx10
  • Name
    sorting nexin 10
  • Synonyms
    2410004M09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919232
    NCBI Gene: 71982
  • Alliance
    gene page
  • Transcription Start Sites
    31 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:51500882-51567659 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 24.95 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2048 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919232
 protein coding gene Chr6:51500881-51567659 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030736
 protein coding gene Chr6:50715619-50792289 (+)
A/J MGP_AJ_G0030706
 protein coding gene Chr6:48354988-48420442 (+)
AKR/J MGP_AKRJ_G0030632
 protein coding gene Chr6:50037681-50107746 (+)
BALB/cJ MGP_BALBcJ_G0030717
 protein coding gene Chr6:48707325-48776423 (+)
C3H/HeJ MGP_C3HHeJ_G0030431
 protein coding gene Chr6:50053379-50122252 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031172
 protein coding gene Chr6:51840075-51919430 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028379
 protein coding gene Chr6:46017055-46071187 (+)
CAST/EiJ MGP_CASTEiJ_G0029833
 protein coding gene Chr6:49829621-49898879 (+)
CBA/J MGP_CBAJ_G0030404
 protein coding gene Chr6:54008763-54075510 (+)
DBA/2J MGP_DBA2J_G0030554
 protein coding gene Chr6:48271027-48337365 (+)
FVB/NJ MGP_FVBNJ_G0030506
 protein coding gene Chr6:47889356-47956349 (+)
LP/J MGP_LPJ_G0030639
 protein coding gene Chr6:50683594-50759559 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030540
 protein coding gene Chr6:56669154-56743469 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031202
 protein coding gene Chr6:49950702-50025629 (+)
PWK/PhJ MGP_PWKPhJ_G0029546
 protein coding gene Chr6:47877582-47946004 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029381
 protein coding gene Chr6:49296615-49366373 (+)
WSB/EiJ MGP_WSBEiJ_G0029910
 protein coding gene Chr6:49954233-50032026 (+)



Homology
more
  • Human Ortholog
    SNX10, sorting nexin 10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNX10, sorting nexin 10
  • Synonyms
    OPTB8
  • Links
    NCBI Gene ID: 29887
    neXtProt AC: NX_Q9Y5X0
    UniProt: Q9Y5X0

  • Chr Location
    7p15.2; chr7:26291862-26374383 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Snx10 mouse models; 1 with human SNX10 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 5 alleles in 4 genetic backgrounds
    10 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele show postnatal growth retardation, failure of tooth eruption, impaired skeleton development, and osteopetrorickets associated with failed osteoclast activity, high stomach pH, low calcium availability, impaired bone mineralization, and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    8
  • cDNA Data
    124
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 71982 NCBI Gene Model | MGI Sequence Detail 66778 C57BL/6J ±  kb
    transcript NM_001361576 RefSeq | MGI Sequence Detail 2616 C57BL/6  
    polypeptide Q9CWT3 UniProt | EBI | MGI Sequence Detail 201 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 127
      cDNA 124
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 8
      Phenotypes 24
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory