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Sars2 Gene Detail
Summary
  • Symbol
    Sars2
  • Name
    seryl-aminoacyl-tRNA synthetase 2
  • Synonyms
    2410015F05Rik, D7Ertd353e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919234
    NCBI Gene: 71984
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28441417-28453296 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.91 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    477 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919234
 protein coding gene Chr7:28441393-28453304 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031957
 protein coding gene Chr7:27573832-27588964 (+)
A/J MGP_AJ_G0031935
 protein coding gene Chr7:26888562-26900745 (+)
AKR/J MGP_AKRJ_G0031867
 protein coding gene Chr7:27580315-27593512 (+)
BALB/cJ MGP_BALBcJ_G0031942
 protein coding gene Chr7:27047940-27060602 (+)
C3H/HeJ MGP_C3HHeJ_G0031661
 protein coding gene Chr7:27956838-27969202 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032406
 protein coding gene Chr7:28474552-28491402 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029458
 protein coding gene Chr7:27949490-27961298 (+)
CAST/EiJ MGP_CASTEiJ_G0030996
 protein coding gene Chr7:21276309-21288854 (+)
CBA/J MGP_CBAJ_G0031627
 protein coding gene Chr7:29746533-29761032 (+)
DBA/2J MGP_DBA2J_G0031779
 protein coding gene Chr7:26642122-26653599 (+)
FVB/NJ MGP_FVBNJ_G0031736
 protein coding gene Chr7:26717609-26731932 (+)
LP/J MGP_LPJ_G0031859
 protein coding gene Chr7:27901615-27913740 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031772
 protein coding gene Chr7:29211880-29232272 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032436
 protein coding gene Chr7:27059778-27072053 (+)
PWK/PhJ MGP_PWKPhJ_G0030721
 protein coding gene Chr7:21665720-21679158 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030554
 protein coding gene Chr7:18078571-18091061 (+)
WSB/EiJ MGP_WSBEiJ_G0031105
 protein coding gene Chr7:27428929-27444046 (+)



Homology
more
  • Human Ortholog
    SARS2, seryl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SARS2, seryl-tRNA synthetase 2, mitochondrial
  • Synonyms
    mtSerRS, SARS, SARSM, SerRS, SerRSmt, SERS, SYS
  • Links
    NCBI Gene ID: 54938
    neXtProt AC: NX_Q9NP81
    UniProt: Q9NP81

  • Chr Location
    19q13.2; chr19:38915266-38930763 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    49
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000070699 Ensembl Gene Model | MGI Sequence Detail 11880 C57BL/6J ±  kb
transcript ENSMUST00000094632 Ensembl | MGI Sequence Detail 1868 Not Applicable  
polypeptide ENSMUSP00000092216 Ensembl | MGI Sequence Detail 518 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000014460 serine--tRNA ligase, mitochondrial
    (term hierarchy)
  • EC
    6.1.1.11
  • InterPro Domains
    IPR006195 Aminoacyl-tRNA synthetase, class II
    IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
    IPR010978 Class I and II aminoacyl-tRNA synthetase, tRNA-binding arm
    IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
    IPR033729 Serine-tRNA ligase catalytic core domain
    IPR002317 Serine-tRNA ligase, type1
    IPR015866 Serine-tRNA synthetase, type1, N-terminal
    IPR042103 Serine-tRNA synthetase, type1, N-terminal domain superfamily
  • GlyGen
    Q9JJL8 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 50
    cDNA 49
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1196425
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 3
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:237827 Gineste C, et al., In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Neuromuscul Disord. 2013 Apr;23(4):357-69
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory