Cnn3 MGI Mouse Gene Detail - MGI:1919244

Symbol

Cnn3
Name

calponin 3, acidic
Synonyms

1600014M03Rik, Calpo3

Feature Type

protein coding gene
IDs

MGI:1919244
NCBI Gene: 71994
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr3:121220190-121251854 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 52.94 cM
Mapping Data

2 experiments

SNPs within 2kb

1078 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919244	protein coding gene	Chr3:121220146-121251856 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027830	protein coding gene	Chr3:123616404-123648382 (+)
A/J	MGP_AJ_G0027788	protein coding gene	Chr3:119497769-119530373 (+)
AKR/J	MGP_AKRJ_G0027754	protein coding gene	Chr3:122543310-122574838 (+)
BALB/cJ	MGP_BALBcJ_G0027800	protein coding gene	Chr3:119317153-119348926 (+)
C3H/HeJ	MGP_C3HHeJ_G0027531	protein coding gene	Chr3:122938056-122970538 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028246	protein coding gene	Chr3:128098832-128132734 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025585	protein coding gene	Chr3:114932082-114963276 (+)
CAST/EiJ	MGP_CASTEiJ_G0026987	protein coding gene	Chr3:122306676-122341332 (+)
CBA/J	MGP_CBAJ_G0027506	protein coding gene	Chr3:132428965-132468550 (+)
DBA/2J	MGP_DBA2J_G0027647	protein coding gene	Chr3:118653910-118686783 (+)
FVB/NJ	MGP_FVBNJ_G0027615	protein coding gene	Chr3:116262346-116295704 (+)
LP/J	MGP_LPJ_G0027757	protein coding gene	Chr3:125138710-125172243 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027645	protein coding gene	Chr3:140066656-140098200 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028302	protein coding gene	Chr3:122093030-122127805 (+)
PWK/PhJ	MGP_PWKPhJ_G0026713	protein coding gene	Chr3:118346691-118379106 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026536	protein coding gene	Chr3:120165518-120196347 (+)
WSB/EiJ	MGP_WSBEiJ_G0027067	protein coding gene	Chr3:122807870-122847698 (+)

Human Ortholog

CNN3, calponin 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CNN3, calponin 3
Links

HGNC:2157

NCBI Gene ID: 1266

neXtProt AC: NX_Q15417

UniProt: Q15417
Chr Location

1p21.3; chr1:94896949-94927223 (-) GRCh38

MGI Vertebrate Homology

Cnn3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CNN3
Gene Tree

Cnn3

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References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 2 alleles in 1 genetic background
1 phenotype from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

95
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

88
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Cnn3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

79 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit severe exencephaly, neuronal tissue overgrowth and die immediately postnatal.

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All GO Annotations

22
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1072
Tissues

34
cDNA Data

205
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cnn3

ZFIN cnn3a

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All Sequences

77
RefSeq

2
UniProt

6
CCDS

CCDS17802.1

Ensembl

ENSMUSG00000053931 (Evidence)
NCBI Gene

71994

			Length	Strain/Species	Flank
genomic	71994	NCBI Gene Model \| MGI Sequence Detail	31665	C57BL/6J	± kb
transcript	NM_028044	RefSeq \| MGI Sequence Detail	2003	C57BL/6
polypeptide	Q9DAW9	UniProt \| EBI \| MGI Sequence Detail	330	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000005642 calponin-3

(term hierarchy)
InterPro Domains

IPR001715 Calponin homology domain

IPR050606 Calponin-like

IPR001997 Calponin/LIMCH1

IPR000557 Calponin repeat

IPR036872 CH domain superfamily

IPR003096 Smooth muscle protein/calponin
GlyGen

Q9DAW9 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 206

cDNA 205

Primer pair 1

Microarray probesets 6

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MGI:2140096

Summaries

All 55

Developmental Gene Expression 10

Diseases 1

Gene Ontology 7

Phenotypes 16
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:289176 Maddala R, et al., Calponin-3 deficiency augments contractile activity, plasticity, fibrogenic response and Yap/Taz transcriptional activation in lens epithelial cells and explants. Sci Rep. 2020 Jan 28;10(1):1295

TSS for Cnn3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31441	Chr3:121220144-121220190 (+)	-23 bp
Tssr31442	Chr3:121220217-121220224 (+)	31 bp
Tssr31443	Chr3:121243329-121243343 (+)	23,146 bp
Tssr31444	Chr3:121243357-121243384 (+)	23,181 bp
Tssr31445	Chr3:121243396-121243413 (+)	23,215 bp
Tssr1033	Chr3:121250313-121250319 (+)	30,126 bp
Tssr31446	Chr3:121250981-121251001 (+)	30,801 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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