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Cnpy3 Gene Detail
Summary
  • Symbol
    Cnpy3
  • Name
    canopy FGF signaling regulator 3
  • Synonyms
    1600025D17Rik, 2410050O22Rik, CAG4A, ERDA5, Tnrc5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919279
    NCBI Gene: 72029
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:47046631-47063140 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 22.90 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    576 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919279
 protein coding gene Chr17:47046631-47063639 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023831
 protein coding gene Chr17:47825781-47846946 (-)
A/J MGP_AJ_G0023789
 protein coding gene Chr17:46669245-46685765 (-)
AKR/J MGP_AKRJ_G0023760
 protein coding gene Chr17:47016851-47032652 (-)
BALB/cJ MGP_BALBcJ_G0023793
 protein coding gene Chr17:46569380-46586733 (-)
C3H/HeJ MGP_C3HHeJ_G0023556
 protein coding gene Chr17:47764747-47783037 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024236
 protein coding gene Chr17:49872948-49893162 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021686
 protein coding gene Chr17:43450152-43465633 (-)
CAST/EiJ MGP_CASTEiJ_G0023038
 protein coding gene Chr17:47855232-47871447 (-)
CBA/J MGP_CBAJ_G0023533
 protein coding gene Chr17:51672405-51686990 (-)
DBA/2J MGP_DBA2J_G0023659
 protein coding gene Chr17:45439085-45454782 (-)
FVB/NJ MGP_FVBNJ_G0023626
 protein coding gene Chr17:45069595-45085761 (-)
LP/J MGP_LPJ_G0023740
 protein coding gene Chr17:48501003-48518404 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023655
 protein coding gene Chr17:51208036-51225633 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024281
 protein coding gene Chr17:47369783-47387772 (-)
PWK/PhJ MGP_PWKPhJ_G0022782
 protein coding gene Chr17:44780268-44796282 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022598
 protein coding gene Chr17:44257378-44272353 (-)
WSB/EiJ MGP_WSBEiJ_G0023103
 protein coding gene Chr17:47929371-47945644 (-)



Homology
more
  • Human Ortholog
    CNPY3, canopy FGF signaling regulator 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNPY3, canopy FGF signaling regulator 3
  • Synonyms
    CAG4A, DEE60, EIEE60, ERDA5, PRAT4A, TNRC5
  • Links
    NCBI Gene ID: 10695
    neXtProt AC: NX_Q9BT09
    UniProt: Q9BT09

  • Chr Location
    6p21.1; chr6:42928002-42939294 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CNPY3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit postnatal growth retardation, postnatal lethality and defects in immune responses mediated by Toll-like receptors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    2
  • cDNA Data
    70
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023973 Ensembl Gene Model | MGI Sequence Detail 16510 C57BL/6J ±  kb
    transcript ENSMUST00000059844 Ensembl | MGI Sequence Detail 1908 Not Applicable  
    polypeptide ENSMUSP00000050309 Ensembl | MGI Sequence Detail 276 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005660 protein canopy homolog 3
      (term hierarchy)
    • InterPro Domains
      IPR021852 Domain of unknown function DUF3456
    • GlyGen
      Q9DAU1 2 sites, 4 N-linked glycans (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 70

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1920935, MGI:2146834
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:289256 Xiao L, et al., RNA-Binding Protein HuR Regulates Paneth Cell Function by Altering Membrane Localization of TLR2 via Post-transcriptional Control of CNPY3. Gastroenterology. 2019 Sep;157(3):731-743
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory