About   Help   FAQ
Tnfrsf13c Gene Detail
Summary
  • Symbol
    Tnfrsf13c
  • Name
    tumor necrosis factor receptor superfamily, member 13c
  • Synonyms
    2010006P15Rik, Baffr, BAFF-R, Bcmd-1, Bcmd1, Lvis22
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919299
    NCBI Gene: 72049
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:82105944-82108570 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 38.56 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    154 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919299
 protein coding gene Chr15:82105943-82108581 (-)
129S1/SvImJ ENSMUSG00200050854
 protein coding gene Chr15:79219866-79222498 (-)
A/J ENSMUSG00195050167
 protein coding gene Chr15:79151503-79154133 (-)
AKR/J ENSMUSG00220052467
 protein coding gene Chr15:79194650-79197279 (-)
BALB/cJ ENSMUSG00180053224
 protein coding gene Chr15:79028441-79031070 (-)
C3H/HeJ ENSMUSG00175044001
 protein coding gene Chr15:79339404-79342034 (-)
C57BL/6NJ ENSMUSG00215046678
 protein coding gene Chr15:79123103-79125729 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020075
 protein coding gene Chr15:76229647-76232194 (-)
CAST/EiJ ENSTCUG00005040144
 protein coding gene Chr15:78645903-78648522 (-)
CBA/J ENSMUSG00210046089
 protein coding gene Chr15:79114503-79117132 (-)
DBA/2J ENSMUSG00185044047
 protein coding gene Chr15:79137684-79140316 (-)
FVB/NJ ENSMUSG00205023978
 protein coding gene Chr15:78867681-78870304 (-)
JF1/MsJ ENSUMUG00000019415
 protein coding gene Chr15:78715941-78718578 (-)
LP/J ENSMUSG00230042222
 protein coding gene Chr15:82460252-82462881 (-)
NOD/ShiLtJ ENSMUSG00190051149
 protein coding gene Chr15:79131597-79134226 (-)
NZO/HlLtJ ENSMUSG00225048533
 protein coding gene Chr15:82798799-82801427 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005038832
 protein coding gene Chr15:79206763-79209397 (-)



Homology
more
  • Human Ortholog
    TNFRSF13C, TNF receptor superfamily member 13C
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFRSF13C, TNF receptor superfamily member 13C
  • Synonyms
    BAFF-R, BAFFR, BROMIX, CD268, CVID4, prolixin
  • Links
    NCBI Gene ID: 115650
    UniProt: Q96RJ3

  • Chr Location
    22q13.2; chr22:41922032-41926806 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TNFRSF13C associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 6 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in defective splenic B-cell maturation, reduced marginal zone B-cell numbers, and impaired T-cell-dependent antibody formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    635
  • Tissues
    27
  • cDNA Data
    19
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068105 Ensembl Gene Model | MGI Sequence Detail 2627 C57BL/6J ±  kb
    transcript ENSMUST00000109535 Ensembl | MGI Sequence Detail 1983 Not Applicable  
    polypeptide ENSMUSP00000105161 Ensembl | MGI Sequence Detail 200 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000001957 tumor necrosis factor receptor superfamily member 13C
      (term hierarchy)
    • InterPro Domains
      IPR043521 Tumor necrosis factor receptor 13C/17
      IPR022338 Tumour necrosis factor receptor 13C
      IPR015336 Tumour necrosis factor receptor 13C, TALL-1 binding domain
    • GlyGen
      Q9D8D0 1 site
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 19
      Primer pair 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-23965, MGI:103101
    References
    more
    • Summaries
      All 151
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 7
      Phenotypes 74
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory