Pard3b MGI Mouse Gene Detail - MGI:1919301 - par-3 family cell polarity regulator beta

Symbol

Pard3b
Name

par-3 family cell polarity regulator beta
Synonyms

1810008K04Rik, 2010002N16Rik, 2810455B10Rik, Als2cr19, PAR3B, PAR3beta, PAR3L

Feature Type

protein coding gene
IDs

MGI:1919301
NCBI Gene: 72823
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr1:61677983-62681443 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 30.92 cM, cytoband C2
Mapping Data

4 experiments

SNPs within 2kb

19930 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919301	protein coding gene	Chr1:61677825-62681443 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016082	protein coding gene	Chr1:61723444-62761258 (+)
A/J	MGP_AJ_G0016065	protein coding gene	Chr1:59563896-60544665 (+)
AKR/J	MGP_AKRJ_G0016021	protein coding gene	Chr1:61242459-62219422 (+)
BALB/cJ	MGP_BALBcJ_G0016020	protein coding gene	Chr1:59610905-60607313 (+)
C3H/HeJ	MGP_C3HHeJ_G0015852	protein coding gene	Chr1:61472006-62482346 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016473	protein coding gene	Chr1:64138230-65170381 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014194	protein coding gene	Chr1:55712872-56678511 (+)
CAST/EiJ	MGP_CASTEiJ_G0015434	protein coding gene	Chr1:60689868-61730873 (+)
CBA/J	MGP_CBAJ_G0015824	protein coding gene	Chr1:66160779-67256704 (+)
DBA/2J	MGP_DBA2J_G0015925	protein coding gene	Chr1:58976707-59956874 (+)
FVB/NJ	MGP_FVBNJ_G0015927	protein coding gene	Chr1:58275497-59258298 (+)
LP/J	MGP_LPJ_G0015997	protein coding gene	Chr1:62599667-63653210 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015947	protein coding gene	Chr1:69069255-70185241 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016520	protein coding gene	Chr1:61161965-62184255 (+)
PWK/PhJ	MGP_PWKPhJ_G0015221	protein coding gene	Chr1:58324024-59327705 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015001	protein coding gene	Chr1:60693871-61693962 (+)
WSB/EiJ	MGP_WSBEiJ_G0015497	protein coding gene	Chr1:60868169-61911607 (+)

Human Ortholog

PARD3B, par-3 family cell polarity regulator beta

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PARD3B, par-3 family cell polarity regulator beta
Synonyms

ALS2CR19, PAR3B, PAR3beta, PAR3L
Links

HGNC:14446

NCBI Gene ID: 117583

neXtProt AC: NX_Q8TEW8

UniProt: Q8TEW8
Chr Location

2q33.3; chr2:204545475-205620162 (+) GRCh38

MGI Vertebrate Homology

Pard3b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PARD3B
Gene Tree

Pard3b

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Pard3b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

64 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

796
Tissues

19
cDNA Data

11
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pard3b

ZFIN pard3ba

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All Sequences

61
RefSeq

10
UniProt

7
CCDS

CCDS48276.1

Ensembl

ENSMUSG00000052062 (Evidence)
NCBI Gene

72823

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052062	Ensembl Gene Model \| MGI Sequence Detail	1003461	C57BL/6J	± kb
transcript	ENSMUST00000075374	Ensembl \| MGI Sequence Detail	8392	Not Applicable
polypeptide	ENSMUSP00000074837	Ensembl \| MGI Sequence Detail	1203	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000012280 partitioning defective 3 homolog B

(term hierarchy)
PDB

1WG6
InterPro Domains

IPR021922 Par3/HAL, N-terminal

IPR052213 Partitioning defective 3 homolog

IPR001478 PDZ domain

IPR036034 PDZ superfamily

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All nucleic 12

Genomic 1

cDNA 11

Microarray probesets 8

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MGI:1916317, MGI:1920073

Summaries

All 47

Developmental Gene Expression 4

Gene Ontology 6

Phenotypes 14
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pard3b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6971	Chr1:61677978-61678000 (+)	6 bp
Tssr6972	Chr1:61678028-61678050 (+)	56 bp
Tssr95	Chr1:61678071-61678082 (+)	94 bp
Tssr6973	Chr1:61678101-61678114 (+)	125 bp
Tssr6974	Chr1:61678152-61678172 (+)	179 bp
Tssr6975	Chr1:61701430-61701431 (+)	23,448 bp
Tssr6976	Chr1:61853257-61853261 (+)	175,276 bp
Tssr6977	Chr1:61913445-61913449 (+)	235,464 bp
Tssr6978	Chr1:61919488-61919492 (+)	241,507 bp
Tssr6979	Chr1:62522553-62522569 (+)	844,578 bp
Tssr6980	Chr1:62561794-62561799 (+)	883,814 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24