Cyp4f18 MGI Mouse Gene Detail - MGI:1919304 - cytochrome P450, family 4, subfamily f, polypeptide 18

Symbol

Cyp4f18
Name

cytochrome P450, family 4, subfamily f, polypeptide 18
Synonyms

1810054N16Rik

Feature Type

protein coding gene
IDs

MGI:1919304
NCBI Gene: 72054
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:72742326-72763470 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 34.67 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

586 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919304	protein coding gene	Chr8:72742326-72763512 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033768	protein coding gene	Chr8:72453868-72474896 (-)
A/J	MGP_AJ_G0033751	protein coding gene	Chr8:69517950-69538957 (-)
AKR/J	MGP_AKRJ_G0033677	protein coding gene	Chr8:71581240-71602248 (-)
BALB/cJ	MGP_BALBcJ_G0033747	protein coding gene	Chr8:69685081-69706123 (-)
C3H/HeJ	MGP_C3HHeJ_G0033456	protein coding gene	Chr8:72172993-72193980 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034265	protein coding gene	Chr8:75187306-75210343 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031206	protein coding gene	Chr8:64104304-64125160 (-)
CAST/EiJ	MGP_CASTEiJ_G0032781	protein coding gene	Chr8:71588343-71609165 (-)
CBA/J	MGP_CBAJ_G0033435	protein coding gene	Chr8:77874580-77895616 (-)
DBA/2J	MGP_DBA2J_G0033588	protein coding gene	Chr8:69221167-69242188 (-)
FVB/NJ	MGP_FVBNJ_G0033532	protein coding gene	Chr8:68312376-68333391 (-)
LP/J	MGP_LPJ_G0033676	protein coding gene	Chr8:72448938-72469953 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033578	protein coding gene	Chr8:80390201-80412287 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034282	protein coding gene	Chr8:71598434-71619459 (-)
PWK/PhJ	MGP_PWKPhJ_G0032489	protein coding gene	Chr8:68499206-68520349 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0032327	protein coding gene	Chr8:70568826-70591487 (-)
WSB/EiJ	MGP_WSBEiJ_G0032898	protein coding gene	Chr8:71952512-71974317 (-)

Human Ortholog

CYP4F2, cytochrome P450 family 4 subfamily F member 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CYP4F2, cytochrome P450 family 4 subfamily F member 2
Synonyms

CPF2
Links

HGNC:2645

NCBI Gene ID: 8529

neXtProt AC: NX_P78329

UniProt: P78329
Chr Location

19p13.12; chr19:15878023-15898077 (-) GRCh38

Human Ortholog

CYP4F3, cytochrome P450 family 4 subfamily F member 3
Synonyms

CPF3, CYP4F, CYPIVF3, LTB4H
Links

HGNC:2646

NCBI Gene ID: 4051

neXtProt AC: NX_Q08477

UniProt: Q08477
Chr Location

19p13.12; chr19:15640897-15662825 (+) GRCh38

MGI Vertebrate Homology

Cyp4f18 stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CYP4F2, CYP4F3
Gene Tree

Cyp4f18

Diseases

1 with human CYP4F8 associations

				Human Disease	Mouse Models
				colorectal adenocarcinoma IDs colorectal adenocarcinoma DOID:0050861 NCI:C5105 UMLS_CUI:C1319315

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

1 involving Cyp4f18
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available

Mice homozygous for a knock-out allele exhibit altered leukotriene B4 metabolism but show no significant alterations in inflammatory cell infiltration or injury following renal ischemia-reperfusion.

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All GO Annotations

25
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

10
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

41
RefSeq

10
UniProt

2
CCDS

CCDS22406.1

Ensembl

ENSMUSG00000003484 (Evidence)
NCBI Gene

72054

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003484	Ensembl Gene Model \| MGI Sequence Detail	21145	C57BL/6J	± kb
transcript	ENSMUST00000003574	Ensembl \| MGI Sequence Detail	1702	Not Applicable
polypeptide	ENSMUSP00000003574	Ensembl \| MGI Sequence Detail	524	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR001128 Cytochrome P450

IPR017972 Cytochrome P450, conserved site

IPR002401 Cytochrome P450, E-class, group I

IPR002403 Cytochrome P450, E-class, group IV

IPR050196 Cytochrome P450 Monooxygenases

IPR036396 Cytochrome P450 superfamily

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 2

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cyp4f18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr81766	Chr8:72763463-72763478 (-)	-1 bp
Tssr81765	Chr8:72756467-72756477 (-)	6,998 bp
Tssr81764	Chr8:72756425-72756432 (-)	7,041 bp
Tssr81763	Chr8:72756393-72756405 (-)	7,071 bp
Tssr81762	Chr8:72756375-72756391 (-)	7,087 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24