Elp6 MGI Mouse Gene Detail - MGI:1919349 - elongator acetyltransferase complex subunit 6

Symbol

Elp6
Name

elongator acetyltransferase complex subunit 6
Synonyms

2610001P13Rik, 2610002I17Rik, Tmem103

Feature Type

protein coding gene
IDs

MGI:1919349
NCBI Gene: 72341
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr9:110134241-110151170 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 59.91 cM
Mapping Data

2 experiments

SNPs within 2kb

572 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919349	protein coding gene	Chr9:110133321-110151170 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035344	protein coding gene	Chr9:112447039-112465704 (+)
A/J	MGP_AJ_G0035325	protein coding gene	Chr9:108360392-108379442 (+)
AKR/J	MGP_AKRJ_G0035256	protein coding gene	Chr9:111052411-111068863 (+)
BALB/cJ	MGP_BALBcJ_G0035320	protein coding gene	Chr9:108103661-108122290 (+)
C3H/HeJ	MGP_C3HHeJ_G0035028	protein coding gene	Chr9:111556849-111575461 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035842	protein coding gene	Chr9:115500273-115518323 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032728	protein coding gene	Chr9:105590149-105604245 (+)
CAST/EiJ	MGP_CASTEiJ_G0034334	protein coding gene	Chr9:111345201-111361019 (+)
CBA/J	MGP_CBAJ_G0034995	protein coding gene	Chr9:119799118-119816491 (+)
DBA/2J	MGP_DBA2J_G0035154	protein coding gene	Chr9:107824236-107841128 (+)
FVB/NJ	MGP_FVBNJ_G0035101	protein coding gene	Chr9:106646594-106664287 (+)
LP/J	MGP_LPJ_G0035233	protein coding gene	Chr9:112741681-112759000 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035141	protein coding gene	Chr9:121158041-121178139 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035862	protein coding gene	Chr9:111375338-111397210 (+)
PWK/PhJ	MGP_PWKPhJ_G0034041	protein coding gene	Chr9:108064113-108079969 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033876	protein coding gene	Chr9:111470196-111486655 (+)
WSB/EiJ	MGP_WSBEiJ_G0034455	protein coding gene	Chr9:111258949-111277463 (+)

Human Ortholog

ELP6, elongator acetyltransferase complex subunit 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ELP6, elongator acetyltransferase complex subunit 6
Synonyms

C3orf75, TMEM103
Links

HGNC:25976

NCBI Gene ID: 54859

neXtProt AC: NX_Q0PNE2

UniProt: Q0PNE2
Chr Location

3p21.31; chr3:47495640-47513712 (-) GRCh38

MGI Vertebrate Homology

Elp6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ELP6
Gene Tree

Elp6

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (ENU)

1
Endonuclease-mediated

3
Gene trapped

11
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced single point mutation exhibit impaired coordination.

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All GO Annotations

27
GO References

9

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

23
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase elp6

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All Sequences

50
RefSeq

7
UniProt

4
CCDS

CCDS52937.1

Ensembl

ENSMUSG00000054836 (Evidence)
NCBI Gene

72341

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054836	Ensembl Gene Model \| MGI Sequence Detail	16930	C57BL/6J	± kb
transcript	ENSMUST00000199592	Ensembl \| MGI Sequence Detail	1304	Not Applicable
polypeptide	ENSMUSP00000142823	Ensembl \| MGI Sequence Detail	266	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000030812 elongator complex protein 6

(term hierarchy)
InterPro Domains

IPR018627 Elongator complex protein 6

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 24

cDNA 24

Microarray probesets 4

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MGI:1919591, MGI:2143264

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Elp6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87343	Chr9:110134253-110134297 (+)	34 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24