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Trub1 Gene Detail
Summary
  • Symbol
    Trub1
  • Name
    TruB pseudouridine (psi) synthase family member 1
  • Synonyms
    2610009I02Rik, 9030425C13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919383
    NCBI Gene: 72133
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:57441344-57479437 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 52.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1412 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919383
 protein coding gene Chr19:57441323-57479437 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025274
 protein coding gene Chr19:57886174-57927334 (+)
A/J MGP_AJ_G0025250
 protein coding gene Chr19:55017287-55055985 (+)
AKR/J MGP_AKRJ_G0025219
 protein coding gene Chr19:56747195-56786106 (+)
BALB/cJ MGP_BALBcJ_G0025245
 protein coding gene Chr19:55089973-55128064 (+)
C3H/HeJ MGP_C3HHeJ_G0025005
 protein coding gene Chr19:56992494-57032091 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025688
 protein coding gene Chr19:59267010-59316160 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023100
 protein coding gene Chr19:53927048-53965913 (+)
CAST/EiJ MGP_CASTEiJ_G0024470
 protein coding gene Chr19:57034143-57073621 (+)
CBA/J MGP_CBAJ_G0024985
 protein coding gene Chr19:62189324-62231474 (+)
DBA/2J MGP_DBA2J_G0025117
 protein coding gene Chr19:54785610-54824086 (+)
FVB/NJ MGP_FVBNJ_G0025078
 protein coding gene Chr19:54518116-54558738 (+)
LP/J MGP_LPJ_G0025203
 protein coding gene Chr19:57721925-57766264 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025111
 protein coding gene Chr19:61431181-61471294 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025746
 protein coding gene Chr19:56958699-56998752 (+)
PWK/PhJ MGP_PWKPhJ_G0024218
 protein coding gene Chr19:54770021-54811824 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024021
 protein coding gene Chr19:55644722-55684019 (+)
WSB/EiJ MGP_WSBEiJ_G0024540
 protein coding gene Chr19:57088596-57131701 (+)



Homology
more
  • Human Ortholog
    TRUB1, TruB pseudouridine synthase family member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRUB1, TruB pseudouridine synthase family member 1
  • Synonyms
    PUS4
  • Links
    NCBI Gene ID: 142940
    neXtProt AC: NX_Q8WWH5
    UniProt: Q8WWH5

  • Chr Location
    10q25.3
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    2
  • cDNA Data
    52
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025086 Ensembl Gene Model | MGI Sequence Detail 38094 C57BL/6J ±  kb
    transcript ENSMUST00000026073 Ensembl | MGI Sequence Detail 3789 Not Applicable  
    polypeptide ENSMUSP00000026073 Ensembl | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 52

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1924279, MGI:2147539, MGI:2147766, MGI:2147777
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory