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Trim29 Gene Detail
Summary
  • Symbol
    Trim29
  • Name
    tripartite motif-containing 29
  • Synonyms
    1110047J21Rik, 2810431N19Rik, 4732461M22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919419
    NCBI Gene: 72169
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:43222145-43247412 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.28 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    783 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919419
 protein coding gene Chr9:43222012-43247422 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034685
 protein coding gene Chr9:41704226-41729588 (+)
A/J MGP_AJ_G0034665
 protein coding gene Chr9:40582426-40607731 (+)
AKR/J MGP_AKRJ_G0034591
 protein coding gene Chr9:41376330-41401657 (+)
BALB/cJ MGP_BALBcJ_G0034656
 protein coding gene Chr9:40308457-40333765 (+)
C3H/HeJ MGP_C3HHeJ_G0034367
 protein coding gene Chr9:41867718-41892888 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035179
 protein coding gene Chr9:42965844-42991194 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032092
 protein coding gene Chr9:40192599-40218389 (+)
CAST/EiJ MGP_CASTEiJ_G0033690
 protein coding gene Chr9:41684126-41810231 (+)
CBA/J MGP_CBAJ_G0034340
 protein coding gene Chr9:44486663-44511971 (+)
DBA/2J MGP_DBA2J_G0034499
 protein coding gene Chr9:40494702-40520007 (+)
FVB/NJ MGP_FVBNJ_G0034439
 protein coding gene Chr9:39738867-39765029 (+)
LP/J MGP_LPJ_G0034580
 protein coding gene Chr9:41993476-42018794 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034483
 protein coding gene Chr9:46432315-46457622 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035198
 protein coding gene Chr9:41283899-41309251 (+)
PWK/PhJ MGP_PWKPhJ_G0033395
 protein coding gene Chr9:40348641-40374270 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033231
 protein coding gene Chr9:41580740-41642156 (+)
WSB/EiJ MGP_WSBEiJ_G0033803
 protein coding gene Chr9:41334567-41361425 (+)



Homology
more
  • Human Ortholog
    TRIM29, tripartite motif containing 29
  • Vertebrate Orthologs
    9
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM29, tripartite motif containing 29
  • Synonyms
    ATDC
  • Links
    NCBI Gene ID: 23650
    neXtProt AC: NX_Q14134
    UniProt: Q14134

  • Chr Location
    11q23.3; chr11:120111286-120185529 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene protects male mice from Coxsackievirus B3-induced myocarditis by enhancing antiviral innate immunity, attenuating inflammation and cardiac damage, and improving cardiac function and survival rates. Primary neonatal cardiomyocytes from mice infected with cardiotropic viruses show reduced ER stress and apoptosis, decreased reactive oxygen species levels, and increased production of type I interferons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    20
  • cDNA Data
    44
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032013 Ensembl Gene Model | MGI Sequence Detail 25268 C57BL/6J ±  kb
    transcript ENSMUST00000034511 Ensembl | MGI Sequence Detail 2735 Not Applicable  
    polypeptide ENSMUSP00000034511 Ensembl | MGI Sequence Detail 587 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 45
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1916090, MGI:1923499, MGI:2142983
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:349246 Wang J, et al., Loss of TRIM29 mitigates viral myocarditis by attenuating PERK-driven ER stress response in male mice. Nat Commun. 2024 Apr 25;15(1):3481
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory