Fbxl20 MGI Mouse Gene Detail - MGI:1919444 - F-box and leucine-rich repeat protein 20

Symbol

Fbxl20
Name

F-box and leucine-rich repeat protein 20
Synonyms

2610511F20Rik, 4632423N09Rik, C86145, Fbl2, Scr, Scrapper

Feature Type

protein coding gene
IDs

MGI:1919444
NCBI Gene: 72194
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:97973382-98041229 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 61.69 cM
Mapping Data

2 experiments

SNPs within 2kb

2097 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919444	protein coding gene	Chr11:97973380-98042014 (-)
129S1/SvImJ	ENSMUSG00200050106	protein coding gene	Chr11:95220713-95289573 (-)
A/J	ENSMUSG00195051746	protein coding gene	Chr11:94943404-95011258 (-)
AKR/J	ENSMUSG00220049662	protein coding gene	Chr11:95202516-95270368 (-)
BALB/cJ	ENSMUSG00180046810	protein coding gene	Chr11:95215186-95283051 (-)
C3H/HeJ	ENSMUSG00175042254	protein coding gene	Chr11:95200784-95269648 (-)
C57BL/6NJ	ENSMUSG00215052910	protein coding gene	Chr11:94791482-94859345 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017075	protein coding gene	Chr11:93865359-93935195 (-)
CAST/EiJ	ENSTCUG00005048104	protein coding gene	Chr11:94654288-94722780 (-)
CBA/J	ENSMUSG00210051925	protein coding gene	Chr11:94905465-94973321 (-)
DBA/2J	ENSMUSG00185045629	protein coding gene	Chr11:95250666-95319531 (-)
FVB/NJ	ENSMUSG00205037108	protein coding gene	Chr11:95117573-95186441 (-)
JF1/MsJ	ENSUMUG00000034594	protein coding gene	Chr11:95553667-95624783 (-)
LP/J	ENSMUSG00230050641	protein coding gene	Chr11:96303595-96372444 (-)
NOD/ShiLtJ	ENSMUSG00190051317	protein coding gene	Chr11:95292658-95360716 (-)
NZO/HlLtJ	ENSMUSG00225050336	protein coding gene	Chr11:98356673-98424506 (-)
PWK/PhJ	ENSLUMG00010050178	protein coding gene	Chr11:95106249-95177038 (-)
SPRET/EiJ	ENSMSPG00010049171	protein coding gene	Chr11:95603528-95670277 (-)
WSB/EiJ	ENSIUOG00005043235	protein coding gene	Chr11:95056597-95125888 (-)

Human Ortholog

FBXL20, F-box and leucine rich repeat protein 20

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXL20, F-box and leucine rich repeat protein 20
Synonyms

Fbl2, Fbl20
Links

HGNC:24679

NCBI Gene ID: 84961

UniProt: Q96IG2
Chr Location

17q12; chr17:39252663-39402556 (-) GRCh38

MGI Vertebrate Homology

Fbxl20 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FBXL20
Gene Tree

Fbxl20

less

Phenotype Summary

10 phenotypes from 3 alleles in 3 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Endonuclease-mediated

3
Gene trapped

18
Targeted

5
Transgenic

3
Genomic Mutations

1 involving Fbxl20
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit some embryonic lethality, shortened lifespans, decreased body size and altered CNS synaptic transmission.

less

All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

672
Tissues

29
cDNA Data

150
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbxl20

less

All Sequences

66
RefSeq

10
UniProt

4
CCDS

CCDS25339.1

Ensembl

ENSMUSG00000020883 (Evidence)
NCBI Gene

72194

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020883	Ensembl Gene Model \| MGI Sequence Detail	67848	C57BL/6J	± kb
transcript	ENSMUST00000103143	Ensembl \| MGI Sequence Detail	8601	Not Applicable
polypeptide	ENSMUSP00000099432	Ensembl \| MGI Sequence Detail	436	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000007379 F-box/LRR-repeat protein 20

(term hierarchy)
InterPro Domains

IPR001810 F-box domain

IPR050648 F-box/Leucine-rich repeat

IPR036047 F-box-like domain superfamily

IPR057207 F-box/LRR-repeat protein 15-like, leucin rich repeat domain

IPR001611 Leucine-rich repeat

IPR006553 Leucine-rich repeat, cysteine-containing subtype

IPR032675 Leucine-rich repeat domain superfamily
GlyGen

Q9CZV8 2 sites, 1 N-linked glycan (1 site)

less

All nucleic 152

cDNA 151

Primer pair 1

Microarray probesets 6

less

MGI:2144301, MGI:2144684, MGI:3034930

Summaries

All 51

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 22
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fbxl20:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110514	Chr11:98040377-98040447 (-)	817 bp
Tssr110513	Chr11:97992333-97992346 (-)	48,889 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24